MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine

Stable Identifier
Reaction [transition]
Homo sapiens
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MRM2 (FTSJ2) located in foci near mitochondrial nucleoids (Lee et al. 2013) transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl of uridine-1369 in 16S rRNA (Lee and Bogenhagen 2014, Rorbach et al. 2014). Inactivation of FTSJ2 causes aberrant assembly of large mitochondrial subunits, reduced mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014).

Literature References
PubMed ID Title Journal Year
25074936 Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA)

Bogenhagen, DF, Lee, KW

J. Biol. Chem. 2014
24036117 Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid

Okot-Kotber, C, Bogenhagen, DF, LaComb, JF, Lee, KW

J. Biol. Chem. 2013
25009282 MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome

Patel, D, Minczuk, M, Rorbach, J, Nicholls, TJ, Perocchi, F, Pearce, SF, Gammage, PA, Boesch, P, Hauser, A

Mol. Biol. Cell 2014
Event Information
Go Biological Process
Catalyst Activity

rRNA (uridine-2'-O-)-methyltransferase activity of FTSJ2 [mitochondrial matrix]

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