Reactome | CCNG1 recruits PP2A-PPP2R5C to MDM2

CCNG1 recruits PP2A-PPP2R5C to MDM2

Stable Identifier

R-HSA-6792871

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)

General

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CCNG1 (cyclin G1) simultaneously interacts with the regulatory subunit of the PP2A protein phosphatase complex, PPP2R5C (Okamoto et al. 1996), and MDM2, thus recruiting the PP2A complex to MDM2 (Okamoto et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11983168	Cyclin G recruits PP2A to dephosphorylate Mdm2 Taya, Y, Li, H, Jensen, MR, Prives, C, Thorgeirsson, SS, Zhang, T, Okamoto, K	Mol. Cell	2002
8887688	p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A Serrano, M, Kamibayashi, C, Mumby, MC, Okamoto, K, Prives, C, Beach, D	Mol. Cell. Biol.	1996