Reactome | 32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm]

32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm]

Stable Identifier

R-HSA-6791562

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

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General

The PeBoW complex and the Rix1:LAS1L:NOL9:SENP3 complex associate with pre-60S ribosome subunits during maturation and are required for efficient rRNA processing. Note that this complex contains many ribsomal subunit proteins and processing factors but the precise composition is not known.

Literature References

PubMed ID	Title	Journal	Year
17353269	Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Orban, M, Rohrmoser, M, Kremmer, E, Pfisterer, I, Hölzel, M	Mol. Cell. Biol.	2007
16738141	Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Rohrmoser, M, Kremmer, E, Hölzel, M	Nucleic Acids Res.	2006
16043514	Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation Gruber-Eber, A, Schlee, M, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Bornkamm, GW, Rohrmoser, M, Hiddemann, W, Kremmer, E, Hölzel, M	J. Cell Biol.	2005
17189298	The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Rohrmoser, M, Kremmer, E, Hölzel, M	Nucleic Acids Res.	2007
22190735	LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis Denicourt, C, Cassimere, EK, Castle, CD	Mol. Biol. Cell	2012