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EXOSC10 [nucleoplasm]
Stable Identifier
R-HSA-6791547
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Exosome component 10 ecNumber3.1.13.-/ecNumber, EXOSX_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01780 EXOSC10
Gene Names
EXOSC10, PMSCL, PMSCL2, RRP6
Chain
chain:1-885
Reference Genes
BioGPS Gene:5394 EXOSC10
COSMIC (genes):EXOSC10 EXOSC10
CTD Gene:5394 EXOSC10
dbSNP Gene:5394 EXOSC10
ENSEMBL:ENSG00000171824 EXOSC10
HGNC:9138 EXOSC10
KEGG Gene (Homo sapiens):5394 EXOSC10
Monarch:5394 EXOSC10
NCBI Gene:5394 EXOSC10
OMIM:605960 EXOSC10
UCSC:Q01780 EXOSC10
Reference Transcript
RefSeq:NM_001001998.2 EXOSC10
RefSeq:NM_002685.3 EXOSC10
Other Identifiers
0000610286
11717510_a_at
11747516_a_at
16681625
207541_s_at
2396481
2396482
2396483
2396484
2396487
2396488
2396489
2396492
2396494
2396496
2396498
2396499
2396500
2396501
2396504
2396507
2396509
2396510
2396512
2396513
2396514
2396517
2396520
2396521
2396522
2396523
2396524
2396525
2396526
2396527
2396529
2396531
2396532
2396533
28470
28484
2CPR
36649_at
37141
3SAF
3SAG
3SAH
5394
6D6Q
6D6R
7912385
89673_s_at
A_23_P62868
AAB59352
AAH39901
AAH73788
AJ300188
AL109811
BC039901
BC073788
CAA46904
CAB037141
CAC15569
CCDS126
CCDS30584
CH471130
EAW71679
ENSG00000171824
ENSP00000307307
ENSP00000366135
ENST00000304457
ENST00000304457.11
ENST00000376936
ENST00000376936.8
EntrezGene:5394
EntrezGene:EXOSC10
EXOSC10
EXOSC10-201
EXOSC10-202
g4505916_3p_a_at
GE59921
GO:0000166
GO:0000175
GO:0000176
GO:0000178
GO:0000184
GO:0000460
GO:0000467
GO:0000956
GO:0003674
GO:0003676
GO:0003723
GO:0003727
GO:0003824
GO:0004518
GO:0004527
GO:0004532
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006139
GO:0006259
GO:0006364
GO:0006396
GO:0006399
GO:0008150
GO:0008408
GO:0009048
GO:0009056
GO:0009058
GO:0016020
GO:0016787
GO:0032211
GO:0032991
GO:0034641
GO:0034655
GO:0035327
GO:0042254
GO:0042592
GO:0043226
GO:0044237
GO:0051276
GO:0070034
GO:0071028
GO:0071034
GO:0071035
GO:0071036
GO:0071037
GO:0071038
GO:0071039
GO:0071040
GO:0071044
GO:0071048
GO:0071051
GO:1904872
HGNC:9138
HPA028470
HPA028484
ILMN_1670796
ILMN_1711189
ILMN_2402168
IPR002121
IPR002562
IPR010997
IPR012337
IPR012588
K7EJ37
L01457
MIM:605960
NM_001001998
NM_002685
NP_001001998
NP_002676
PF00570
PF01612
PF08066
PH_hs_0023791
PH_hs_0032653
SM00341
SM00474
TC01002196.hg
UPI0000000CD8
UPI0000001C90
X66113
X66113_s_at
XM_005263475
XM_017001495
XM_017001497
XP_005263532
XP_016856984
XP_016856986
XR_002956818
XR_002956819
XR_002956820
XR_002956821
XR_002956822
Participant Of
hasComponent
EXOSC10:C1D:MPHOSPH6 [nucleoplasm]
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
Inferred To
EXOSC10 [nucleoplasm] (Bos taurus)
EXOSC10 [nucleoplasm] (Caenorhabditis elegans)
EXOSC10 [nucleoplasm] (Canis familiaris)
EXOSC10 [nucleoplasm] (Danio rerio)
EXOSC10 [nucleoplasm] (Dictyostelium discoideum)
EXOSC10 [nucleoplasm] (Drosophila melanogaster)
EXOSC10 [nucleoplasm] (Gallus gallus)
EXOSC10 [nucleoplasm] (Mus musculus)
EXOSC10 [nucleoplasm] (Rattus norvegicus)
EXOSC10 [nucleoplasm] (Saccharomyces cerevisiae)
EXOSC10 [nucleoplasm] (Schizosaccharomyces pombe)
EXOSC10 [nucleoplasm] (Sus scrofa)
EXOSC10 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_002676.1
,
NP_001001998.1
OpenTargets
ENSG00000171824
GeneCards
Q01780
PRO
Q01780
PDB
3SAF
,
6D6R
,
3SAH
,
2CPR
,
3SAG
,
6D6Q
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13868 EXOSC2
2
EXOSC2 [cytosol]
(R-HSA-429999)
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
0.788
5
UniProt:Q9Y3B2 EXOSC1
2
EXOSC1 [cytosol]
(R-HSA-429841)
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
0.758
4
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
EXOSC5 [cytosol]
(R-HSA-429889)
0.752
4
UniProt:Q99547 MPHOSPH6
1
MPHOSPH6 [nucleoplasm]
(R-HSA-6791553)
0.75
4
UniProt:Q9NPD3 EXOSC4
2
EXOSC4 [cytosol]
(R-HSA-430013)
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
0.738
4
UniProt:Q9Y2L1 DIS3
2
DIS3 [cytosol]
(R-HSA-429935)
DIS3 [nucleoplasm]
(R-HSA-6791517)
0.738
4
UniProt:Q15024 EXOSC7
2
EXOSC7 [cytosol]
(R-HSA-430030)
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
0.678
3
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.65
5
UniProt:Q06265 EXOSC9
2
EXOSC9 [cytosol]
(R-HSA-429984)
EXOSC9 [nucleoplasm]
(R-HSA-6791577)
0.643
3
UniProt:Q9NQT5 EXOSC3
2
EXOSC3 [cytosol]
(R-HSA-430017)
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
0.643
4
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.547
2
UniProt:Q96B26 EXOSC8
2
EXOSC8 [cytosol]
(R-HSA-429912)
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
0.547
2
UniProt:Q8TF46 DI3L1
0.527
2
UniProt:P17844 DDX5
3
SUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
DDX5 [nucleoplasm]
(R-HSA-3900136)
SUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.524
3
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