Reactome | FTSJ3 [nucleoplasm]

FTSJ3 [nucleoplasm]

Stable Identifier

R-HSA-6791507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"pre-rRNA processing protein FTSJ3 ecNumber evidence="2"2.1.1.-/ecNumber, SPB1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q53GL0 PKHO1

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Literature References

PubMed ID	Title	Journal	Year
22195017	The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing Zanchin, NI, Nickerson, JA, Singh, G, Silva, TC, Coltri, PP, Quaresma, AJ, Moore, MJ, Morello, LG, Oliveira, CC, Simabuco, FM	PLoS ONE	2011

External Reference Information

External Reference

UniProt:Q8IY81 FTSJ3

Gene Names

FTSJ3, SB92

Chain

chain:1-847

Reference Genes

BioGPS Gene:117246 FTSJ3

COSMIC (genes):FTSJ3 FTSJ3

CTD Gene:117246 FTSJ3

dbSNP Gene:117246 FTSJ3

ENSEMBL:ENSG00000108592 FTSJ3

ENSEMBL_homo_sapiens_GENE:ENSG00000108592.17 FTSJ3

HGNC:17136 FTSJ3

KEGG Gene (Homo sapiens):117246 FTSJ3

Monarch:117246 FTSJ3

NCBI Gene:117246 FTSJ3

OMIM:618411 FTSJ3

UCSC:Q8IY81 FTSJ3

Reference Transcript

RefSeq:NM_017647.3 FTSJ3

Other Identifiers

11719034_a_at

117246

11750693_a_at

16847621

218103_PM_at

218103_at

3766374

3766375

3766376

3766377

3766378

3766379

3766380

3766381

3766383

3766385

3766386

3766387

3766388

3766390

3766392

3766393

3766394

3766395

3766396

3766398

3766399

3766400

3766401

3766403

3766404

3766405

3766406

3766407

3766409

3766410

43464_at

8017437

A_23_P55091

GE82194

GO:0000463

GO:0000466

GO:0001510

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006364

GO:0008168

GO:0008173

GO:0008649

GO:0008650

GO:0016435

GO:0016740

GO:0030687

GO:0030688

GO:0031167

GO:0032259

GO:0042254

GO:0043226

GO:0062105

GO:0140098

HMNXSV003041175

ILMN_1811692

PH_hs_0013527

TC17001786.hg

g8923066_3p_at

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Inferred To

FTSJ3 [nucleoplasm] (Bos taurus)

FTSJ3 [nucleoplasm] (Canis familiaris)

FTSJ3 [nucleoplasm] (Mus musculus)

FTSJ3 [nucleoplasm] (Rattus norvegicus)

FTSJ3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_060117.3

OpenTargets

ENSG00000108592

GeneCards

Q8IY81

HPA

ENSG00000108592-FTSJ3

Ensembl

ENSG00000108592, ENSP00000396673, ENST00000427159

PRO

Q8IY81

Pharos - Targets

Q8IY81

Orphanet

24548

HMDB Protein

HMDBP09032

PDB

8FKR, 8IR1, 8FKW, 8FKU, 8FKP, 8FKX, 8FKY, 8FKS, 8FKV, 8FKT, 8FKQ

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.669	4
UniProt:Q9UPE1 SRPK3			0.643	3
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.623	3
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.564	2
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.564	2
UniProt:Q16385-2 Q163852			0.556	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	3
UniProt:P42696 RBM34			0.527	3
UniProt:Q15020 SART3			0.527	3
UniProt:Q9NZM5 NOP53			0.527	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	3
UniProt:Q9BXY0 MAK16			0.527	2
UniProt:Q53GL0 PKHO1			0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:P10074 TZAP			0.527	2
UniProt:Q9H6Y2 WDR55			0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	3
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.527	3
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	3
UniProt:Q96HE9 PRR11			0.527	2
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.527	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	3
UniProt:Q9Y6K5 OAS3	1	OAS3 [cytosol] (R-HSA-1015672)	0.499	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.462	2

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