Reactome | TP53 binds the APAF1 gene promoter

TP53 binds the APAF1 gene promoter

Stable Identifier

R-HSA-6791349

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        TP53 binds the APAF1 gene promoter (Homo sapiens)

General

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TP53 (p53) binds the p53 response element in the promoter of the APAF1 gene (Robles et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11559530	APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis Robles, AI, Bemmels, NA, Foraker, AB, Harris, CC	Cancer Res.	2001

Participants

Input

Output

p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

TP53 Regulates Transcription of Caspase Activators and Caspases

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-08-20)

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