TP53 stimulates AIFM2 gene expression

Stable Identifier
R-HSA-6791306
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, nucleoplasm
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TP53 stimulates AIFM2 gene expression
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TP53 (p53) directly stimulates transcription of the AIFM2 (AMID) gene upon binding to p53 response elements in the promoter of the AIFM2 gene. AIFM2 encodes a mitochondrial outer membrane protein implicated in caspase-independent apoptosis (Wu et al. 2004).

Literature References
PubMed ID Title Journal Year
15273740 AMID is a p53-inducible gene downregulated in tumors

Wu, M, Xu, LG, Su, T, Tian, Y, Zhai, Z, Shu, HB

Oncogene 2004
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This event is regulated
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-08-20)