Reactome | TP53 stimulates AIFM2 gene expression

TP53 stimulates AIFM2 gene expression

Stable Identifier

R-HSA-6791306

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates AIFM2 gene expression (Homo sapiens)

General

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TP53 (p53) directly stimulates transcription of the AIFM2 (AMID) gene upon binding to p53 response elements in the promoter of the AIFM2 gene. AIFM2 encodes a mitochondrial outer membrane protein implicated in caspase-independent apoptosis (Wu et al. 2004).

Literature References