TP53 stimulates AIFM2 gene expression

Stable Identifier
R-HSA-6791306
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, nucleoplasm
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TP53 stimulates AIFM2 gene expression
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TP53 (p53) directly stimulates transcription of the AIFM2 (AMID) gene upon binding to p53 response elements in the promoter of the AIFM2 gene. AIFM2 encodes a mitochondrial outer membrane protein implicated in caspase-independent apoptosis (Wu et al. 2004).

Literature References
PubMed ID Title Journal Year
15273740 AMID is a p53-inducible gene downregulated in tumors

Su, T, Zhai, Z, Wu, M, Shu, HB, Tian, Y, Xu, LG

Oncogene 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:AIFM2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-08-20)
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