Reactome | TP53 binds the AIFM2 gene promoter

TP53 binds the AIFM2 gene promoter

Stable Identifier

R-HSA-6791302

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the AIFM2 gene promoter (Homo sapiens)

General

SBML |

SVG | | PPTX | SBGN

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) binds the promoter of the AIFM2 (AMID) gene, which contains two p53 response elements (Wu et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15273740	AMID is a p53-inducible gene downregulated in tumors Wu, M, Xu, LG, Su, T, Tian, Y, Zhai, Z, Shu, HB	Oncogene	2004

Participants

Input

Output

p-S15,S20-TP53 Tetramer:AIFM2 Gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-08-20)