Reactome | TP53 binds the AIFM2 gene promoter

TP53 binds the AIFM2 gene promoter

Stable Identifier

R-HSA-6791302

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the AIFM2 gene promoter (Homo sapiens)

General

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TP53 (p53) binds the promoter of the AIFM2 (AMID) gene, which contains two p53 response elements (Wu et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15273740	AMID is a p53-inducible gene downregulated in tumors Wu, M, Xu, LG, Su, T, Tian, Y, Zhai, Z, Shu, HB	Oncogene	2004

Participants

Input

Output

p-S15,S20-TP53 Tetramer:AIFM2 Gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-08-20)