Release of NS1 homodimer

Stable Identifier
R-HSA-6791035
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Release of NS1 homodimer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once the NS1 homodimer is imported into the nucleus, the importin complex releases the NS1 homodimer.

Literature References
PubMed ID Title Journal Year
10846107 Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication

Bergmann, M, Garcia-Sastre, A, Carnero, E, Pehamberger, H, Wolff, K, Palese, P, Muster, T

J. Virol. 2000
10205180 Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery

Chen, Z, Li, Y, Krug, RM

EMBO J 1999
9651582 Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs

Nemeroff, ME, Barabino, SM, Li, Y, Keller, W, Krug, RM

Mol Cell 1998
8313914 Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport

Fortes, P, Beloso, A, Ortin, J

EMBO J 1994
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
Gillespie, ME  (2015-08-17)
Cite Us!