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TRMT112 [nucleoplasm]
Stable Identifier
R-HSA-6790984
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Multifunctional methyltransferase subunit TRM112-like protein, TR112_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)
WBSCR22:TRIMT112 [nucleoplasm] (Homo sapiens)
TRMT112 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25851604
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
Nicolas, E
,
Huvelle, E
,
Zorbas, C
,
Heurgué-Hamard, V
,
Wacheul, L
,
Lafontaine, DL
Mol. Biol. Cell
2015
External Reference Information
External Reference
UniProt:Q9UI30 TRMT112
Gene Names
TRMT112, AD-001, HSPC152, HSPC170
Chain
chain:1-125
Reference Genes
BioGPS Gene:51504 TRMT112
COSMIC (genes):TRMT112 TRMT112
CTD Gene:51504 TRMT112
dbSNP Gene:51504 TRMT112
ENSEMBL:ENSG00000173113 TRMT112
ENSEMBL:ENSG00000173113.7 TRMT112
HGNC:26940 TRMT112
KEGG Gene (Homo sapiens):51504 TRMT112
Monarch:51504 TRMT112
NCBI Gene:51504 TRMT112
OMIM:618630 TRMT112
UCSC:Q9UI30 TRMT112
Reference Transcript
RefSeq:NM_001286082.1 TRMT112
RefSeq:NM_016404.2 TRMT112
Other Identifiers
11756380_s_at
11756381_x_at
16739887
217774_PM_s_at
217774_s_at
2545051
2545052
3376866
3376868
3376869
3376870
3376871
3376873
3376875
3376878
51504
65948_at
7949075
A_23_P12992
A_24_P283814
GE86245
GO:0002940
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006364
GO:0006399
GO:0008276
GO:0016740
GO:0018364
GO:0030488
GO:0031167
GO:0032991
GO:0036211
GO:0042254
GO:0043226
GO:0045815
GO:0046982
GO:0048471
GO:0070476
GO:0140096
GO:2000234
HMNXSV003002192
ILMN_1690802
PH_hs_0023844
PH_hs_0035798
TC11001904.hg
g7705476_3p_a_at
Participates
as a component of
WBSCR22:TRIMT112 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TRMT112 [cytosol]
Cross References
RefSeq
NP_001273011.1
,
NP_057488.1
OpenTargets
ENSG00000173113
HPA
ENSG00000173113-TRMT112
GeneCards
Q9UI30
Ensembl
ENSP00000438349
,
ENST00000544844
,
ENSP00000309433
,
ENSG00000173113
,
ENST00000308774
PRO
Q9UI30
Pharos - Targets
Q9UI30
PDB
6PED
,
6H2V
,
7WTV
,
6H1E
,
7WTW
,
7WTS
,
6G4W
,
6K0X
,
6KMR
,
7WTT
,
6H2U
,
7WTU
,
6KHS
,
6KMS
,
6H1D
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43709 BUD23
1
WBSCR22 [nucleoplasm]
(R-HSA-6790981)
0.831
10
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