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WBSCR22 [nucleoplasm]
Stable Identifier
R-HSA-6790981
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Probable 18S rRNA, WBS22_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
WBSCR22 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)
WBSCR22:TRIMT112 [nucleoplasm] (Homo sapiens)
WBSCR22 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25851604
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
Nicolas, E
,
Huvelle, E
,
Zorbas, C
,
Heurgué-Hamard, V
,
Wacheul, L
,
Lafontaine, DL
Mol. Biol. Cell
2015
External Reference Information
External Reference
UniProt:O43709 WBSCR22
Gene Names
WBSCR22, MERM1, HUSSY-03, PP3381, BUD23
Chain
chain:1-281
Reference Genes
BioGPS Gene:114049 WBSCR22
COSMIC (genes):BUD23 WBSCR22
CTD Gene:114049 WBSCR22
dbSNP Gene:114049 WBSCR22
ENSEMBL:ENSG00000071462 WBSCR22
HGNC:16405 WBSCR22
Monarch:114049 WBSCR22
NCBI Gene:114049 WBSCR22
OMIM:615733 WBSCR22
UCSC:O43709 WBSCR22
Reference Transcript
RefSeq:NM_001202560.2 WBSCR22
RefSeq:NM_017528.4 WBSCR22
Other Identifiers
114049
11741995_x_at
11744826_x_at
11744987_x_at
11747422_a_at
207628_PM_s_at
207628_s_at
3007895
3007896
3007897
3007904
3007905
3007906
3007907
3007908
3007910
3007912
3007913
3007917
3007918
3007919
40090_at
8133345
A_23_P71014
A_33_P3414487
GE55249
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006325
GO:0006364
GO:0008168
GO:0008757
GO:0016435
GO:0016740
GO:0032259
GO:0042254
GO:0043226
GO:0046982
GO:0048471
GO:0070476
GO:0140098
GO:2000234
HMNXSV003045747
ILMN_1697348
PH_hs_0024923
TC07002401.hg
g8923713_3p_a_at
Participates
as a component of
WBSCR22:TRIMT112 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
(Homo sapiens)
Inferred To
BUD23 [nucleoplasm]
(Bos taurus)
Bud23 [nucleoplasm]
(Mus musculus)
Bud23 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000265758
,
ENST00000265758
OpenTargets
ENSG00000071462
HPA
ENSG00000071462-BUD23
PRO
O43709
Pharos - Targets
O43709
GlyGen
O43709
HMDB Protein
HMDBP12007
PDB
6G4W
,
7WTS
,
7WTW
,
7WTU
,
7WTT
,
7WTV
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UI30 TRMT112
2
TRMT112 [nucleoplasm]
(R-HSA-6790984)
TRMT112 [cytosol]
(R-HSA-6786545)
0.882
12
UniProt:Q9C0C9 UBE2O
1
UBE2O [cytosol]
(R-HSA-947641)
0.643
4
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