NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447

Stable Identifier
R-HSA-6790944
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447
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NOP2 methylates the carbon at the 5th position of the cytosine ring at cytidine-4447 in 28S rRNA (Bourgeois et al. 2015). NOP2 also has a role in rRNA processing that is independent of its methylase activity.
Literature References
PubMed ID Title Journal Year
26196125 Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

Bourgeois, G, Ney, M, Gaspar, I, Aigueperse, C, Schaefer, M, Kellner, S, Helm, M, Motorin, Y

PLoS ONE 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
rRNA methylation (0031167)
Catalyst Activity

rRNA (cytosine-C5-)-methyltransferase activity of NOP2 [nucleoplasm]

Physical Entity
NOP2 [nucleoplasm] (Homo sapiens)
Activity
rRNA (cytosine-C5-)-methyltransferase activity (GO:0009383)
Inferred From
NOP2 methylates cytosine-2870 of 25S rRNA yielding 5-methylcytosine-2870 (Saccharomyces cerevisiae)
Authored
May, B  (2015-08-15)
Reviewed
Vincent, NG  (2016-01-30)
Sharma, S  (2016-02-12)
Created
May, B  (2015-08-15)
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