NOP2 methylates the carbon at the 5th position of the cytosine ring at cytidine-4447 in 28S rRNA (Bourgeois et al. 2015). NOP2 also has a role in rRNA processing that is independent of its methylase activity.
Schaefer, M, Ney, M, Kellner, S, Motorin, Y, Aigueperse, C, Bourgeois, G, Gaspar, I, Helm, M
rRNA (cytosine-C5-)-methyltransferase activity of NOP2 [nucleoplasm]
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