Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA

Stable Identifier
R-HSA-6790905
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA
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Box H/ACA snoRNP complexes convert uridine to pseudouridine at 97 sites in human 28S, 18S, and 5.8S rRNAs (Kiss et al. 2004, reviewed in Ge and Yu 2013). The box H/ACA snoRNA component guides the complex to specific residues of the rRNAs by base pairing between the regions of the snoRNA and the rRNA (Kiss et al. 2004, Xiao et al. 2009). The human genome encodes more than 80 box H/ACA snoRNAs (Lestrade and Weber 2006).
Literature References
PubMed ID Title Journal Year
19033376 Functionality and substrate specificity of human box H/ACA guide RNAs

Xiao, M, Yang, C, Schattner, P, Yu, YT

RNA 2009
16381836 snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs

Lestrade, L, Weber, MJ

Nucleic Acids Res. 2006
15199136 Human box H/ACA pseudouridylation guide RNA machinery

Kiss, AM, Jády, BE, Bertrand, E, Kiss, T

Mol. Cell. Biol. 2004
23391857 RNA pseudouridylation: new insights into an old modification

Ge, J, Yu, YT

Trends Biochem. Sci. 2013
Participants
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Output
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Event Information
Go Biological Process
rRNA pseudouridine synthesis (0031118)
Catalyst Activity

pseudouridine synthase activity of Box H/ACA snoRNP [nucleoplasm]

Physical Entity
Box H/ACA snoRNP [nucleoplasm] (Homo sapiens)
Activity
pseudouridine synthase activity (GO:0009982)
Authored
May, B  (2015-08-12)
Reviewed
Vincent, NG  (2016-01-30)
Sharma, S  (2016-02-12)
Created
May, B  (2015-08-15)
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