Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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Box H/ACA snoRNP complexes convert uridine to pseudouridine at 97 sites in human 28S, 18S, and 5.8S rRNAs (Kiss et al. 2004, reviewed in Ge and Yu 2013). The box H/ACA snoRNA component guides the complex to specific residues of the rRNAs by base pairing between the regions of the snoRNA and the rRNA (Kiss et al. 2004, Xiao et al. 2009). The human genome encodes more than 80 box H/ACA snoRNAs (Lestrade and Weber 2006).

Literature References
PubMed ID Title Journal Year
19033376 Functionality and substrate specificity of human box H/ACA guide RNAs

Schattner, P, Yang, C, Yu, YT, Xiao, M

RNA 2009
16381836 snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs

Weber, MJ, Lestrade, L

Nucleic Acids Res. 2006
15199136 Human box H/ACA pseudouridylation guide RNA machinery

Kiss, AM, Kiss, T, Bertrand, E, Jády, BE

Mol. Cell. Biol. 2004
23391857 RNA pseudouridylation: new insights into an old modification

Yu, YT, Ge, J

Trends Biochem. Sci. 2013
Event Information
Catalyst Activity

pseudouridine synthase activity of Box H/ACA snoRNP [nucleoplasm]

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