HVEM induses BTLA phosphorylation

Stable Identifier
R-HSA-6790087
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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HVEM induses BTLA phosphorylation
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Binding of HVEM to BTLA induces tyrosine phosphorylation of BTLA on three cytoplasmic tyrosines. The phosphorylated tyrosine Y274 and 299 ( Y257 and 282 in human BTLA) associate with tyrosine phosphatase SHP2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al. 2006).
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Hvem induses Btla phosphorylation (Mus musculus)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2015-08-07)
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