HVEM induses BTLA phosphorylation

Stable Identifier
R-HSA-6790087
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HVEM induses BTLA phosphorylation
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of HVEM to BTLA induces tyrosine phosphorylation of BTLA on three cytoplasmic tyrosines. The phosphorylated tyrosine Y274 and 299 ( Y257 and 282 in human BTLA) associate with tyrosine phosphatase SHP2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al. 2006).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Hvem induses Btla phosphorylation (Mus musculus)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2015-08-07)
Cite Us!