Expression of STAT3-upregulated cytosolic proteins

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for cytoplasmic proteins upregulated by STAT3 include Suppressor of cytokine signaling 3 (SOCS3) (He et al. 2003), Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) (Becker et al. 2014), Heat shock protein HSP 90-alpha (HSP90AA1) (Chen et al. 2007), Fascin (FSCN1) (Snyder et al. 2011), Vimentin (VIM) (Wu et al. 2004), Rho-related GTP-binding protein RhoU (RHOU) (Schiavone et al. 2009), RAC-alpha serine/threonine-protein kinase (AKT1) (Xu et al. 2005), Cyclin-dependent kinase inhibitor 1 (CDKN1A) (Bellido et al. 1998), Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) (Abell et al. 2005), Signal transducer and activator of transcription 1 (STAT1) (Han et al. 2013), Interferon regulatory factor 4 (IRF4) (Durant et al. 2010) and Nitric oxide synthase, inducible (NOS2) (Lo et al. 2005).
Literature References
PubMed ID Title Journal Year
15950906 Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

Gunduz, M, Lo, HW, Xia, W, Bartholomeusz, G, Ali-Seyed, M, Hung, MC, Shih, JY, Wei, Y, Hsu, SC

Cancer Cell 2005
22693070 STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3

Lo, HW, Carpenter, RL, Han, W, Cao, X

Mol. Carcinog. 2013
20493732 Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis

Sun, HW, Durant, L, O'Shea, JJ, Laurence, A, Kanno, Y, Ramos, HL, Powrie, F, Watford, WT, Wei, L, Takahashi, H, Vahedi, G

Immunity 2010
14712222 Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89

Izmailova, ES, Zhang, X, Diab, I, Wu, Y, Zehner, ZE

Oncogene 2004
21937440 Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration

Zhang, JJ, Snyder, M, Huang, XY

J. Biol. Chem. 2011
23455323 Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

Mann, GJ, Mijatov, B, Zhang, XD, Snoyman, S, Kefford, RF, Rizos, H, Becker, TM, Scolyer, RA, Gowrishankar, K, Boyd, SC, Pupo, GM

Oncogene 2014
16007214 Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Briggs, J, Zhang, S, Xu, Q, Park, S, Gritsko, T, Yu, H, Niu, G, Kortylewski, M, Kay, H, Jove, R, Semenza, GL, Turkson, J, Cheng, JQ

Oncogene 2005
17427945 Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock

Chen, XS, Shen, YF, Li, XY, Cheng, XK, Wang, JS, Zhang, Y, Zhang, Y, Wu, NH

J. Cell. Biochem. 2007
19397496 The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

Schiavone, D, Di Cunto, F, Poli, V, Turkson, J, Dewilde, S, Vallania, F

Biochem. J. 2009
24743777 STAT3 Target Genes Relevant to Human Cancers

Lo, HW, Carpenter, RL

Cancers (Basel) 2014
This event is regulated
Cite Us!