Expression of HSP90B1

Stable Identifier
R-HSA-6790038
Type
Reaction [omitted]
Species
Homo sapiens
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the gene which encodes the endoplasmic reticulum lumen protein Endoplasmin (HSP90B1) (Madamanchi et al. 2001).

Literature References
PubMed ID Title Journal Year
11278437 Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway

Madamanchi, NR, Li, S, Patterson, C, Runge, MS

J. Biol. Chem. 2001
24743777 STAT3 Target Genes Relevant to Human Cancers

Carpenter, RL, Lo, HW

Cancers (Basel) 2014
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