Reactome | Expression of HSP90B1

Expression of HSP90B1

Stable Identifier

R-HSA-6790038

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, nucleoplasm

ReviewStatus

5/5

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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the gene which encodes the endoplasmic reticulum lumen protein Endoplasmin (HSP90B1) (Madamanchi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
24743777	STAT3 Target Genes Relevant to Human Cancers Lo, HW, Carpenter, RL	Cancers (Basel)	2014
11278437	Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway Li, S, Runge, MS, Madamanchi, NR, Patterson, C	J. Biol. Chem.	2001