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Expression of HSP90B1
Stable Identifier
R-HSA-6790038
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of HSP90B1 (Homo sapiens)
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the gene which encodes the endoplasmic reticulum lumen protein Endoplasmin (HSP90B1) (Madamanchi et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
24743777
STAT3 Target Genes Relevant to Human Cancers
Lo, HW
,
Carpenter, RL
Cancers (Basel)
2014
11278437
Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway
Li, S
,
Runge, MS
,
Madamanchi, NR
,
Patterson, C
J. Biol. Chem.
2001
Participants
Output
HSP90B1 [endoplasmic reticulum lumen]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
This event is regulated
Positively by
Regulator
p-Y705-STAT3 dimer [nucleoplasm]
(Homo sapiens)
Orthologous Events
Expression of HSP90B1 (Bos taurus)
Expression of HSP90B1 (Caenorhabditis elegans)
Expression of HSP90B1 (Canis familiaris)
Expression of HSP90B1 (Danio rerio)
Expression of HSP90B1 (Dictyostelium discoideum)
Expression of HSP90B1 (Drosophila melanogaster)
Expression of HSP90B1 (Gallus gallus)
Expression of HSP90B1 (Mus musculus)
Expression of HSP90B1 (Rattus norvegicus)
Expression of HSP90B1 (Sus scrofa)
Expression of HSP90B1 (Xenopus tropicalis)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-08-06)
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