Expression of STAT3-upregulated nuclear proteins

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R-HSA-6790036
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Reaction [omitted]
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Homo sapiens
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for nuclear proteins upregulated by STAT3 include CCAAT/enhancer-binding protein delta (CEBPD) (Hutt et al. 2000), B-cell lymphoma 6 protein (BCL6) (Reljic et al. 2000), Myc proto-oncogene protein (MYC) (Kiuchi et al. 1999, Bowman et al. 2001), Proto-oncogene c-Fos (FOS) (Yang et al. 2003), Hypoxia-inducible factor 1-alpha (HIF1A) (Niu et al. 2008), Transcription factor SOX-2 (SOX2) (Foshay & Gallicano 2008), the homeobox protein NANOG (Okumura et al. 2011), Twist-related protein 1 (TWIST1) (Lo et al. 2007, Cheng et al. 2008), Zinc finger E-box-binding homeobox 1 (ZEB1) (Xiong et al. 2012), POU domain, class 2, transcription factor 1 (POU2F1) (OCT1) (Wang et al. 2013), Baculoviral IAP repeat-containing protein 5 (BIRC5, Survivin) (Gritsko et al. 2006), G1/S-specific cyclin-D1 (CCND1) (Leslie et al. 2006), Serine/threonine-protein kinase PIM1 (Przanowski et al. 2014), Forkhead box protein O1 (FOXO1), FOXO3 (Oh et al. 2011), Nuclear receptor ROR-alpha (RORA), RORC, Basic leucine zipper transcriptional factor ATF-like (BATF) (Durant et al. 2010) and Transcription factor JUNB (Coffer et al. 1995).

Literature References
PubMed ID Title Journal Year
24097101 The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

Przanowski, P, Dabrowski, M, Ellert-Miklaszewska, A, Kloss, M, Mieczkowski, J, Kaza, B, Ronowicz, A, Hu, F, Piotrowski, A, Kettenmann, H, Komorowski, J, Kaminska, B

J. Mol. Med. 2014
16510571 Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3

Leslie, K, Lang, C, Devgan, G, Azare, J, Berishaj, M, Gerald, W, Kim, YB, Paz, K, Darnell, JE, Albanese, C, Sakamaki, T, Pestell, R, Bromberg, J

Cancer Res. 2006
16397018 Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

Gritsko, T, Williams, A, Turkson, J, Kaneko, S, Bowman, T, Huang, M, Nam, S, Eweis, I, Diaz, N, Sullivan, D, Yoder, S, Enkemann, S, Eschrich, S, Lee, JH, Beam, CA, Cheng, J, Minton, S, Muro-Cacho, CA, Jove, R

Clin. Cancer Res. 2006
15950906 Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

Lo, HW, Hsu, SC, Ali-Seyed, M, Gunduz, M, Xia, W, Wei, Y, Bartholomeusz, G, Shih, JY, Hung, MC

Cancer Cell 2005
12600988 Independent and cooperative activation of chromosomal c-fos promoter by STAT3

Yang, E, Lerner, L, Besser, D, Darnell, JE

J. Biol. Chem. 2003
18353781 Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

Cheng, GZ, Zhang, WZ, Sun, M, Wang, Q, Coppola, D, Mansour, M, Xu, LM, Costanzo, C, Cheng, JQ, Wang, LH

J. Biol. Chem. 2008
20493732 Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis

Durant, L, Watford, WT, Ramos, HL, Laurence, A, Vahedi, G, Wei, L, Takahashi, H, Sun, HW, Kanno, Y, Powrie, F, O'Shea, JJ

Immunity 2010
22205702 Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition

Xiong, H, Hong, J, Du, W, Lin, YW, Ren, LL, Wang, YC, Su, WY, Wang, JL, Cui, Y, Wang, ZH, Fang, JY

J. Biol. Chem. 2012
7898939 Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction

Coffer, P, Lutticken, C, van Puijenbroek, A, Klop-de Jonge, M, Horn, F, Kruijer, W

Oncogene 1995
18447642 Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate

Foshay, KM, Gallicano, GI

Stem Cells Dev. 2008
24743777 STAT3 Target Genes Relevant to Human Cancers

Carpenter, RL, Lo, HW

Cancers (Basel) 2014
23172665 STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1

Wang, Z, Zhu, S, Shen, M, Liu, J, Wang, M, Li, C, Wang, Y, Deng, A, Mei, Q

Carcinogenesis 2013
18644974 Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

Niu, G, Briggs, J, Deng, J, Ma, Y, Lee, H, Kortylewski, M, Kujawski, M, Kay, H, Cress, WD, Jove, R, Yu, H

Mol. Cancer Res. 2008
11404481 Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T, Broome, MA, Sinibaldi, D, Wharton, W, Pledger, WJ, Sedivy, JM, Irby, R, Yeatman, T, Courtneidge, SA, Jove, R

Proc. Natl. Acad. Sci. U.S.A. 2001
9874564 STAT3 is required for the gp130-mediated full activation of the c-myc gene

Kiuchi, N, Nakajima, K, Ichiba, M, Fukada, T, Narimatsu, M, Mizuno, K, Hibi, M, Hirano, T

J. Exp. Med. 1999
11120780 Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6

Reljic, R, Wagner, SD, Peakman, LJ, Fearon, DT

J. Exp. Med. 2000
10867011 Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland

Hutt, JA, O'Rourke, JP, DeWille, J

J. Biol. Chem. 2000
21730069 STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors

Oh, HM, Yu, CR, Golestaneh, N, Amadi-Obi, A, Lee, YS, Eseonu, A, Mahdi, RM, Egwuagu, CE

J. Biol. Chem. 2011
21689689 TRIM8 regulates Nanog via Hsp90ß-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F, Okumura, AJ, Matsumoto, M, Nakayama, KI, Hatakeyama, S

Biochim. Biophys. Acta 2011
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