Expression of STAT3-upregulated plasma membrane proteins

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Reaction [omitted]
Homo sapiens
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for plasma membrane proteins that are upregulated by STAT3 include Intercellular adhesion molecule 1 (ICAM1) (Scuringa et al. 2001), Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B, TNFR2) (Hamilton et al. 2011), Sphingosine 1-phosphate receptor 1 (S1PR1, EDG1) (Lee et al. 2010), Interleukin-6 receptor subunit alpha (IL6R), Interleukin-23 receptor (IL23R) (Durant et al. 2010) and Mucin-1 (MUC1) (Gaemers et al. 2001).

Literature References
PubMed ID Title Journal Year
21994466 Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells

Van Landeghem, L, Lund, PK, Simmons, JG, Ding, S, Hamilton, KE

Mol. Cancer Res. 2011
20493732 Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis

Sun, HW, Durant, L, O'Shea, JJ, Laurence, A, Kanno, Y, Ramos, HL, Powrie, F, Watford, WT, Wei, L, Takahashi, H, Vahedi, G

Immunity 2010
11356008 c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE)

Vellenga, E, Timmer, H, Schuringa, JJ, Kruijer, W, Luttickhuizen, D

Cytokine 2001
21102457 STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

Jove, R, Lee, H, Forman, S, Herrmann, A, Horne, D, Yu, H, Yang, C, Somlo, G, Liu, Y, Kujawski, M, Kortylewski, M, Deng, J

Nat. Med. 2010
24743777 STAT3 Target Genes Relevant to Human Cancers

Lo, HW, Carpenter, RL

Cancers (Basel) 2014
11084045 A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells

Hilkens, J, Vos, HL, van der Valk, SW, Gaemers, IC, Volders, HH

J. Biol. Chem. 2001
16606674 Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

Yoshimura, T, Kobayashi, T, Fukuyama, S, Inoue, H, Kinjyo, I, Koga, K, Takaki, H, Yoshimura, A, Himeno, K, Hamano, S, Takaesu, G

J. Exp. Med. 2006
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