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Expression of IL4,IL13-downregulated extracellular genes
Stable Identifier
R-HSA-6789524
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
,
nucleoplasm
ReviewStatus
5/5
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)
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In human peripheral blood, monocytes Interleukin-4 (IL4) and Interleukin-13 significantly downregulate the expression of classical proinflammatory signal transducers, such as Interleukin-1 (IL1), Interleukin-6, Interleukin-8, Interleukin-18, C-C motif chemokine 2 (CCL2) and Tumor necrosis factor (TNF). Expression of Prostaglandin G/H synthase 2 (PTGS2, COX2) and Arachidonate 5-lipoxygenase (ALOX5), enzymes involved in the biosynthesis of the proinflammatory eicosanoids, is also attenuated (Chatidis et al. 2005).
This is a black box event because the mechanism of gene regulation is not fully defined.
Literature References
PubMed ID
Title
Journal
Year
15869882
Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13
Chaitidis, P
,
Bermudez-Fajardo, A
,
Kuban, RJ
,
O'Donnell, V
,
Kühn, H
,
Ungethuem, U
Cytokine
2005
Participants
Input
IL4,IL13-downregulated genes for extracellular proteins [nucleoplasm]
(Homo sapiens)
Output
IL4,IL13-downregulated extracellular proteins [extracellular region]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
This event is regulated
Negatively by
Regulator
IL4, IL13 [extracellular region]
(Homo sapiens)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-07-31)
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