Lipases are enzymes that hydrolyse dietary lipids such as fats, oils and triglycerides. The majority of human lipases are secreted by the pancreas and function mainly in the digestive system. Lipase members K, M and N (LIPK, M and N), however, all appear to play a role in the last step of keratinocyte differentiation where they are proposed to hydrolyse triglycerides to free fatty acids and glycerol which is essential to stratum corneum hydration (Toulza et al. 2007).
Serre, G, Guerrin, M, Jacob, D, Dossat, C, Galliano, MF, de Daruvar, A, Mattiuzzo, NR, Toulza, E, Wincker, P, Jonca, N
lipoprotein lipase activity of keratinocyte LIPs [extracellular region]
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