Reactome | LIPs hydrolyse TG to DAG and RCOOH

LIPs hydrolyse TG to DAG and RCOOH

Stable Identifier

R-HSA-6789310

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Lipases are enzymes that hydrolyse dietary lipids such as fats, oils and triglycerides. The majority of human lipases are secreted by the pancreas and function mainly in the digestive system. Lipase members K, M and N (LIPK, M and N), however, all appear to play a role in the last step of keratinocyte differentiation where they are proposed to hydrolyse triglycerides to free fatty acids and glycerol which is essential to stratum corneum hydration (Toulza et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17562024	Large-scale identification of human genes implicated in epidermal barrier function Toulza, E, Mattiuzzo, NR, Galliano, MF, Jonca, N, Dossat, C, Jacob, D, de Daruvar, A, Wincker, P, Serre, G, Guerrin, M	Genome Biol.	2007