Reactome | Myeloperoxidase (MPO) binds to the bacterial cell surface

Myeloperoxidase (MPO) binds to the bacterial cell surface

Stable Identifier

R-HSA-6789136

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

phagocytic vesicle, phagocytic vesicle lumen, plasma membrane

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Myeloperoxidase (MPO) binds to the bacterial cell surface

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Association of MPO with the surfaces of ingested bacteria has been observed microscopically (Selvaraj RJ et al. 1978). This could be a way of directing HOCl for effective killing (Klebanoff SJ et al. 1999). MPO has been shown to bind to the surface of a number of species (Miyasaki KT et al. 1987). However, even with MPO binding, most of the H2O2 would react with unbound MPO.

Literature References

PubMed ID	Title	Journal	Year
206633	Enhanced killing of myeloperoxidase-coated bacteria in the myeloperoxidase-H2O2-Cl- system Selvaraj, RJ, Zgliczynski, JM, Paul, BB, Sbarra, AJ	J. Infect. Dis.	1978
10519157	Myeloperoxidase Klebanoff, SJ	Proc. Assoc. Am. Physicians	1999
3032796	Role of high-avidity binding of human neutrophil myeloperoxidase in the killing of Actinobacillus actinomycetemcomitans Miyasaki, KT, Zambon, JJ, Jones, CA, Wilson, ME	Infect. Immun.	1987
17074761	Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing Winterbourn, CC, Hampton, MB, Livesey, JH, Kettle, AJ	J. Biol. Chem.	2006