Association of MPO with the surfaces of ingested bacteria has been observed microscopically (Selvaraj RJ et al. 1978). This could be a way of directing HOCl for effective killing (Klebanoff SJ et al. 1999). MPO has been shown to bind to the surface of a number of species (Miyasaki KT et al. 1987). However, even with MPO binding, most of the H2O2 would react with unbound MPO.
Selvaraj, RJ, Zgliczynski, JM, Paul, BB, Sbarra, AJ
Klebanoff, SJ
Miyasaki, KT, Zambon, JJ, Jones, CA, Wilson, ME
Winterbourn, CC, Hampton, MB, Livesey, JH, Kettle, AJ
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