Reactome | FN3KRP phosphorylates PsiAm, RibAm

FN3KRP phosphorylates PsiAm, RibAm

Stable Identifier

R-HSA-6788855

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Proteins can undergo chemical modifications such as glycation, which occurs when glucose and other free aldoses spontaneously react with N-terminal and eta-amino groups of proteins to form Schiff bases, which slowly rearrange to ketosamines or, if the sugar was glucose, fructosamines. Fructosamines can further react slowly and become advanced glycation end products, which are thought to play a role in the pathophysiology of several disorders, especially diabetic complications. Ketosamine-3-kinase (FN3K) and ketosamine-3-kinase-related protein (FN3KRP) can phosphorylate protein-bound or free ketosamines on the third carbon of the sugar moiety and the resultant, unstable ketosamine 3-phosphates decompose under physiological conditions (a process called deglycation). Both enzymes can 3-phosphorylate psicosamines (PsiAm) and ribulosamines (RibAm) (Collard et al. 2003, 2004), but only FN3K can 3-phosphorylate fructosamines (FruAm) as well.

Literature References

PubMed ID	Title	Journal	Year
14633848	A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines Matthijs, G, Stroobant, V, Delpierre, G, Van Schaftingen, E, Collard, F	Diabetes	2003
15137908	Fructosamine 3-kinase-related protein and deglycation in human erythrocytes Delpierre, G, Vanstapel, F, Wiame, E, Vertommen, D, Bergans, N, Van Schaftingen, E, Fortpied, J, Collard, F	Biochem. J.	2004