Reactome | AK4 phosphorylates (d)NMPs to (d)NDPs

AK4 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier

R-HSA-6788798

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated. Adenylate kinase 4 (AK4) can mediate nucleotide homeostasis in the mitochondrion (Panayiotou et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19766732	Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4 Panayiotou, C, Solaroli, N, Johansson, M, Karlsson, A	Int. J. Biochem. Cell Biol.	2010