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TRMT13 2'-O-methylates cytidine-4 in tRNA
Stable Identifier
R-HSA-6788684
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As inferred from the yeast homolog, TRMT13 methylates the 2' hydroxyl group of cytidine-4 in the acceptor stems of tRNA(Gly) and tRNA(Pro). The subcellular location of the reaction is unknown. Yeast lacking TRM13 do not have an obvious growth defect.
Participants
Input
AdoMet [cytoplasm]
tRNA(Gly,Pro) containing C-4 [cytoplasm]
(Homo sapiens)
Output
AdoHcy [cytoplasm]
tRNA(Gly,Pro) containing 2'-O-methylC-4 [cytoplasm]
(Homo sapiens)
Participates
as an event of
tRNA modification in the nucleus and cytosol (Homo sapiens)
Event Information
Go Biological Process
tRNA methylation (0030488)
Catalyst Activity
tRNA 2'-O-methyltransferase activity of TRMT13 [cytoplasm]
Physical Entity
TRMT13 [cytoplasm]
(Homo sapiens)
Activity
tRNA 2'-O-methyltransferase activity (GO:0106050)
Inferred From
TRM13 2'-O-methylates cytidine-4 in tRNA (Saccharomyces cerevisiae)
Authored
May, B (2015-07-23)
Reviewed
Levinger, L (2015-08-11)
Motorin, Y (2015-08-25)
Jarrous, N (2015-10-24)
Created
May, B (2015-07-24)
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