As inferred from the yeast homolog, TRMT13 methylates the 2' hydroxyl group of adenosine-4 in the acceptor stems of tRNA(His). The subcellular location of the reaction is unknown. Yeast lacking TRM13 do not have an obvious growth defect.
tRNA (cytosine-2'-O-)-methyltransferase activity of TRMT13 [cytoplasm]
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