STAT1,STAT3,STAT6 phosphorylation

Stable Identifier
R-HSA-6788582
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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STAT1,STAT3,STAT6 phosphorylation
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Once bound to the Interleukin-13 (IL13) type II receptor, Signal transducer and activator of transcription 3 (STAT3) is tyrosine phosphorylated by Janus kinase 2 (JAK2), while STAT1 and STAT6 are phosphorylated by Non-receptor tyrosine kinase 2 (TYK2) (Bhattacharjee et al. 2013).
Literature References
PubMed ID Title Journal Year
23124025 IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

Bhattacharjee, A, Shukla, M, Yakubenko, VP, Mulya, A, Kundu, S, Cathcart, MK

Free Radic. Biol. Med. 2013
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Catalyst Activity

non-membrane spanning protein tyrosine kinase activity of IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane]

Physical Entity
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine kinase activity (GO:0004715)
Orthologous Events
STAT1,STAT3,STAT6 phosphorylation (Bos taurus)
STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)
STAT1,STAT3,STAT6 phosphorylation (Mus musculus)
STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)
STAT1,STAT3,STAT6 phosphorylation (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-23)
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