Reactome | NDUFAF7 [mitochondrial matrix]

NDUFAF7 [mitochondrial matrix]

Stable Identifier

R-HSA-6788525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

NADH dehydrogenase [ubiquinone] complex I, assembly factor 7, NDUF7_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport (Homo sapiens)
    - Complex I biogenesis (Homo sapiens)
      - IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - NDUF subunits bind to form the IP subcomplex (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7L592 NDUFAF7

Gene Names

NDUFAF7, C2orf56, PRO1853

Chain

transit peptide:1-46, chain:47-441

Reference Genes

BioGPS Gene:55471 NDUFAF7

COSMIC (genes):NDUFAF7 NDUFAF7

CTD Gene:55471 NDUFAF7

dbSNP Gene:55471 NDUFAF7

ENSEMBL:ENSG00000003509 NDUFAF7

HGNC:28816 NDUFAF7

KEGG:hsa:55471 NDUFAF7

Monarch:55471 NDUFAF7

NCBI Gene:55471 NDUFAF7

OMIM:615898 NDUFAF7

UCSC:Q7L592 NDUFAF7

Reference Transcript

Other Identifiers

11727826_a_at

11727827_x_at

11746711_a_at

16879145

220943_PM_s_at

220943_s_at

223560_PM_s_at

223560_s_at

230379_3p_x_at

230379_PM_x_at

230379_x_at

2477373

2477374

2477375

2477376

2477377

2477378

2477379

2477380

2477383

2477384

2477385

2477386

2477387

2477388

2477389

2477390

2477391

2477392

2477394

2477395

2477396

2477397

2477398

2477399

2477400

2477401

2477402

2477403

2477406

51806_i_at

55471

8041495

A_14_P131798

A_23_P28318

GE63145

GO:0003824

GO:0005515

GO:0005615

GO:0005739

GO:0005759

GO:0008168

GO:0016740

GO:0019899

GO:0019918

GO:0032259

GO:0032981

GO:0035243

GO:0043226

GO:0065003

GO:0140096

HMNXSV003022606

Hs.52891.2.A1_3p_at

ILMN_1722186

ILMN_1787370

ILMN_2394132

PH_hs_0020124

TC02000235.hg

g13528701_3p_s_at

Participates

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)

Inferred To

ndufaf7 [mitochondrial matrix] (Danio rerio)

ndufaf7 [mitochondrial matrix] (Xenopus tropicalis)

midA [mitochondrial matrix] (Dictyostelium discoideum)

NDUFAF7 [mitochondrial matrix] (Bos taurus)

NDUFAF7 [mitochondrial matrix] (Caenorhabditis elegans)

NDUFAF7 [mitochondrial matrix] (Canis familiaris)

NDUFAF7 [mitochondrial matrix] (Drosophila melanogaster)

NDUFAF7 [mitochondrial matrix] (Gallus gallus)

NDUFAF7 [mitochondrial matrix] (Sus scrofa)

Ndufaf7 [mitochondrial matrix] (Mus musculus)

Ndufaf7 [mitochondrial matrix] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000336237, ENST00000002125, ENSP00000337431, ENSP00000002125, ENSG00000003509

OpenTargets

ENSG00000003509

GeneCards

NDUFAF7

HPA

ENSG00000003509-NDUFAF7

PRO

Q7L592

Pharos - Targets

Q7L592

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	2

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