Reactome | NDUFAF7 [mitochondrial matrix]

NDUFAF7 [mitochondrial matrix]

Stable Identifier

R-HSA-6788525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

NADH dehydrogenase [ubiquinone] complex I, assembly factor 7, NDUF7_HUMAN

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        NDUF subunits bind to form the IP subcomplex (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
        
        IP subcomplex [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)
        
        NDUFAF7 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7L592 NDUFAF7

Gene Names

NDUFAF7, C2orf56, PRO1853

Chain

transit peptide:1-46, chain:47-441

Reference Genes

BioGPS Gene:55471 NDUFAF7

COSMIC (genes):NDUFAF7 NDUFAF7

CTD Gene:55471 NDUFAF7

dbSNP Gene:55471 NDUFAF7

ENSEMBL:ENSG00000003509 NDUFAF7

ENSEMBL_homo_sapiens_GENE:ENSG00000003509.16 NDUFAF7

HGNC:28816 NDUFAF7

KEGG Gene (Homo sapiens):55471 NDUFAF7

Monarch:55471 NDUFAF7

NCBI Gene:55471 NDUFAF7

OMIM:615898 NDUFAF7

UCSC:Q7L592 NDUFAF7

Reference Transcript

Other Identifiers

11727826_a_at

11727827_x_at

11746711_a_at

16879145

220943_PM_s_at

220943_s_at

223560_PM_s_at

223560_s_at

230379_3p_x_at

230379_PM_x_at

230379_x_at

2477373

2477374

2477376

2477377

2477378

2477379

2477380

2477383

2477384

2477389

2477391

2477392

2477394

2477395

2477397

2477398

2477399

2477400

2477401

2477402

51806_i_at

55471

8041495

A_14_P131798

A_23_P28318

GE63145

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005739

GO:0005759

GO:0007005

GO:0008168

GO:0008757

GO:0016740

GO:0019899

GO:0019918

GO:0032259

GO:0032981

GO:0035243

GO:0036211

GO:0043226

GO:0065003

GO:0140096

HMNXSV003022606

Hs.52891.2.A1_3p_at

ILMN_1722186

ILMN_1787370

ILMN_2394132

PH_hs_0020124

TC02000235.hg

g13528701_3p_s_at

Participates

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)

Inferred To

ndufaf7 [mitochondrial matrix] (Danio rerio)

ndufaf7 [mitochondrial matrix] (Xenopus tropicalis)

midA [mitochondrial matrix] (Dictyostelium discoideum)

NDUFAF7 [mitochondrial matrix] (Bos taurus)

NDUFAF7 [mitochondrial matrix] (Caenorhabditis elegans)

NDUFAF7 [mitochondrial matrix] (Canis familiaris)

NDUFAF7 [mitochondrial matrix] (Drosophila melanogaster)

NDUFAF7 [mitochondrial matrix] (Gallus gallus)

NDUFAF7 [mitochondrial matrix] (Sus scrofa)

Ndufaf7 [mitochondrial matrix] (Mus musculus)

Ndufaf7 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_653337.1, NP_001077415.1

OpenTargets

ENSG00000003509

HPA

ENSG00000003509-NDUFAF7

GeneCards

Q7L592

Ensembl

ENST00000002125, ENSP00000337431, ENST00000336237, ENSP00000002125, ENSG00000003509

PRO

Q7L592

Pharos - Targets

Q7L592

Orphanet

24743

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	2

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