Expression of IL13-upregulated plasma membrane proteins

Stable Identifier
R-HSA-6788346
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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Expression of IL13-upregulated plasma membrane proteins
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In monocytes and macrophages Interleukin-13 (IL13) enhances the expression of many members of the integrin family including Integrin alpha M (ITGAM, CD11b), Integrin alpha-X (ITGAX, CD11c), Integrin beta 2 (ITGB2, CD18) and Integrin beta 1 (ITGB1, CD29) (Zurawski & de Vries 1994), MHC class II and ow affinity immunoglobulin epsilon Fc receptor (FCER2, CD23) expression (de Vries 1998). In endothelial cells IL13 induces expression of Vascular cell adhesion protein 1 (VCAM1), which is important in the recruitment of eosinophils (Bochner et al. 1995).
Literature References
PubMed ID Title Journal Year
9723655 The role of IL-13 and its receptor in allergy and inflammatory responses

de Vries, JE

J. Allergy Clin. Immunol. 1998
7907877 Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

Zurawski, G, de Vries, JE

Immunol. Today 1994
7529288 IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells

Bochner, BS, Klunk, DA, Sterbinsky, SA, Coffman, RL, Schleimer, RP

J. Immunol. 1995
Participants
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Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IL13 [extracellular region] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-20)
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