Expression of IL13-upregulated plasma membrane proteins

Stable Identifier
R-HSA-6788346
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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Expression of IL13-upregulated plasma membrane proteins
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In monocytes and macrophages Interleukin-13 (IL13) enhances the expression of many members of the integrin family including Integrin alpha M (ITGAM, CD11b), Integrin alpha-X (ITGAX, CD11c), Integrin beta 2 (ITGB2, CD18) and Integrin beta 1 (ITGB1, CD29) (Zurawski & de Vries 1994), MHC class II and ow affinity immunoglobulin epsilon Fc receptor (FCER2, CD23) expression (de Vries 1998). In endothelial cells IL13 induces expression of Vascular cell adhesion protein 1 (VCAM1), which is important in the recruitment of eosinophils (Bochner et al. 1995).
Literature References
PubMed ID Title Journal Year
9723655 The role of IL-13 and its receptor in allergy and inflammatory responses

de Vries, JE

J. Allergy Clin. Immunol. 1998
7907877 Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

Zurawski, G, de Vries, JE

Immunol. Today 1994
7529288 IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells

Coffman, RL, Schleimer, RP, Sterbinsky, SA, Klunk, DA, Bochner, BS

J. Immunol. 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IL13 [extracellular region] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-20)
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