IL34 dimer binds CSF1R

Stable Identifier
R-HSA-6787820
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Synonyms
Interleukin-34 binds CSF1R
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IL34 dimer binds CSF1R
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The receptor for Interleukin-34 (IL34) is colony stimulating factor 1 receptor (CSF1R), also called macrophage colony stimulating factor receptor (M-CSF-R). Dimeric IL34 and CSF1 bind the same general region of CSF1R, interacting with overlapping but distinct epitopes. Ligand binding leads to receptor dimerisation (Ma et al. 2012, Liu et al. 2012). Like CSF1, IL34 stimulation of CSF1R leads to phosphorylation of extracellular signal-regulated kinase (ERK) 1 and 2 in human monocytes (Lin et al. 2008). CSF1R activates several signaling pathways including JAK-STAT3, 5A/B, phosphorylation of PIK3R1, PLCG2, GRB2, SLA2 and CBL. PLCG2 phosphorylation leads to increassed production of the cellular signaling molecules diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (IP3), which activate protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3 kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of MAPK1 (ERK2) or MAPK3 (ERK1) and the SRC family kinases SRC, FYN and YES1. Activated CSF1R binds GRB2 and promotes tyrosine phosphorylation of SHC1 and INPP5D (SHIP1). Signaling is down regulated by protein phosphatases such as INPP5D that can dephosphorylate the receptor and its downstream effectors.

Literature References
PubMed ID Title Journal Year
18467591 Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

Lin, H, Lee, E, Hestir, K, Leo, C, Huang, M, Bosch, E, Halenbeck, R, Wu, G, Zhou, A, Behrens, D, Hollenbaugh, D, Linnemann, T, Qin, M, Wong, J, Chu, K, Doberstein, SK, Williams, LT

Science 2008
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Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2015-07-17)