Reactome | GRK7 [photoreceptor disc membrane]

GRK7 [photoreceptor disc membrane]

Stable Identifier

R-HSA-6787797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

photoreceptor disc membrane

Synonyms

G protein-coupled receptor kinase 7 ecNumber evidence="8"2.7.11.14/ecNumber ecNumber2.7.11.16/ecNumber, GRK7_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)
        
        GRK1,4,7 [photoreceptor disc membrane] (Homo sapiens)
        
        GRK7 [photoreceptor disc membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WTQ7 GRK7

Gene Names

GRK7, GPRK7

Chain

chain:1-550, propeptide:551-553

Reference Genes

BioGPS Gene:131890 GRK7

COSMIC (genes):GRK7 GRK7

CTD Gene:131890 GRK7

dbSNP Gene:131890 GRK7

ENSEMBL:ENSG00000114124 GRK7

HGNC:17031 GRK7

KEGG Gene (Homo sapiens):131890 GRK7

Monarch:131890 GRK7

NCBI Gene:131890 GRK7

OMIM:606987 GRK7

UCSC:Q8WTQ7 GRK7

Reference Transcript

Other Identifiers

0001500176

11715215_s_at

11759382_at

131890

1552929_at

16946453

2645721

2645723

2645724

2645725

2645726

2645727

2645728

2645729

2645741

2645746

2645747

2645748

8083129

A_14_P113450

A_23_P425176

A_33_P3226910

AAL33880

AAL48216

AC112504

AF282269

AF439409

CCDS3120

ENSG00000114124

ENSP00000264952

ENST00000264952

ENST00000264952.2

EntrezGene:131890

EntrezGene:GRK7

GE558602

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004703

GO:0005524

GO:0005575

GO:0005623

GO:0005929

GO:0006464

GO:0006468

GO:0007165

GO:0007601

GO:0008150

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0022400

GO:0043167

GO:0043226

GO:0046777

GO:0050254

GO:0050877

GO:0050896

GO:0097381

GRK7

GRK7-201

HGNC:17031

Hs2.351818.1.S2_3p_x_at

ILMN_1767827

IPR000239

IPR000719

IPR000961

IPR008271

IPR011009

IPR016137

IPR017441

IPR036305

MIM:606987

NM_139209

NP_631948

PF00069

PF00615

PH_hs_0035508

PR00717

SM00133

SM00220

SM00315

TC03000765.hg

UPI000004244D

XM_017005717

XP_016861206

Participant Of

hasMember

GRK1,4,7 [photoreceptor disc membrane]

Inferred To

GRK7 [photoreceptor disc membrane] (Danio rerio)

GRK7 [photoreceptor disc membrane] (Sus scrofa)

GRK7 [photoreceptor disc membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_631948.1, XP_016861206.1

ZINC - World Drugs

GRK7_HUMAN

OpenTargets

ENSG00000114124

ZINC - FDA approved

GRK7_HUMAN

ZINC - Substances

GRK7_HUMAN

ZINC target

Q8WTQ7

ZINC - Biogenic

GRK7_HUMAN

PRO

Q8WTQ7

ZINC - Investigational

GRK7_HUMAN

IntEnz

2.7.11.14

GeneCards

Q8WTQ7

ZINC - Predictions - Purchasable

GRK7_HUMAN

HMDB Protein

HMDBP09511