Reactome | GRK7 [photoreceptor disc membrane]

GRK7 [photoreceptor disc membrane]

Stable Identifier

R-HSA-6787797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

photoreceptor disc membrane

Synonyms

G protein-coupled receptor kinase 7 ecNumber evidence="8"2.7.11.14/ecNumber ecNumber2.7.11.16/ecNumber, GRK7_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8WTQ7 GRK7

Gene Names

GRK7, GPRK7

Chain

chain:1-550, propeptide:551-553

Reference Genes

BioGPS Gene:131890 GRK7

COSMIC (genes):GRK7 GRK7

CTD Gene:131890 GRK7

dbSNP Gene:131890 GRK7

ENSEMBL:ENSG00000114124 GRK7

HGNC:17031 GRK7

KEGG:hsa:131890 GRK7

Monarch:131890 GRK7

NCBI Gene:131890 GRK7

OMIM:606987 GRK7

UCSC:Q8WTQ7 GRK7

Reference Transcript

Other Identifiers

11715215_s_at

11759382_at

131890

1552929_PM_at

1552929_at

16946453

2645719

2645721

2645723

2645724

2645725

2645726

2645727

2645728

2645729

2645741

2645746

2645747

2645748

8083129

A_14_P113450

A_23_P425176

A_33_P3226910

GE558602

GO:0003824

GO:0004672

GO:0004674

GO:0004703

GO:0005515

GO:0005524

GO:0005737

GO:0006468

GO:0007165

GO:0007601

GO:0009966

GO:0016020

GO:0016740

GO:0022400

GO:0046777

GO:0050254

GO:0050877

GO:0097381

GO:0140096

HMNXSV003029755

HMNXSV003044889

Hs2.351818.1.S2_3p_x_at

ILMN_1767827

PH_hs_0035508

TC03000765.hg

Participates

as a member of

GRK1,4,7 [photoreceptor disc membrane] (Homo sapiens)

Inferred To

GRK7 [photoreceptor disc membrane] (Bos taurus)

GRK7 [photoreceptor disc membrane] (Caenorhabditis elegans)

GRK7 [photoreceptor disc membrane] (Canis familiaris)

GRK7 [photoreceptor disc membrane] (Danio rerio)

GRK7 [photoreceptor disc membrane] (Gallus gallus)

GRK7 [photoreceptor disc membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1471

ENSEMBL

ENSP00000508022, ENST00000264952, ENSP00000264952, ENST00000682958, ENSG00000114124

OpenTargets

ENSG00000114124

ZINC - FDA approved

GRK7_HUMAN

ZINC - Substances

GRK7_HUMAN

ZINC - Biogenic

GRK7_HUMAN

ZINC target

Q8WTQ7

PRO

Q8WTQ7

GlyGen

Q8WTQ7

ZINC - Investigational

GRK7_HUMAN

IntEnz

2.7.11.14

GeneCards

GRK7

HPA

ENSG00000114124-GRK7

Pharos - Targets

Q8WTQ7

ZINC - Predictions - Purchasable

GRK7_HUMAN

HMDB Protein

HMDBP09511

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:Q0VG06 FAAP100	2	FAAP100 [nucleoplasm] (R-HSA-419545) FAAP100 [cytosol] (R-HSA-420799)	0.499	2