Reactome | FUOM isomerises alpha-Fuc to beta-Fuc

FUOM isomerises alpha-Fuc to beta-Fuc

Stable Identifier

R-HSA-6787677

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        GDP-fucose biosynthesis (Homo sapiens)
        
        FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)

General

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L-Fucose (6-deoxy-L-galactose) exists in two different forms, alpha-L-fucose (29.5%) and beta-L-fucose (70.5%). The beta-form is metabolised through the salvage pathway to ultimately form GDP-fucose. Fucose mutarotase (FUOM) is involved in the anomeric conversions of monosaccharides, converting alpha-Fuc to beta-Fuc (Timson & Reece 2003).

Literature References