GDP-fucose biosynthesis

Stable Identifier
R-HSA-6787639
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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GDP-fucose biosynthesis
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Fucose-containing glycans play important roles in immunity and signalling. Fucosylated glycans are created by fucosyltransferases, which require the high-energy donor substrate GDP-fucose. Two pathways for the synthesis of GDP-fucose exist in mammalian cells; the GDP-mannose-dependent de novo pathway provides the majority of GDP-fucose whereas a minor contribution comes from the free fucose-dependent salvage pathway (Becker & Lowe 2003).
Literature References
PubMed ID Title Journal Year
12651883 Fucose: biosynthesis and biological function in mammals

Lowe, JB, Becker, DJ

Glycobiology 2003
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Event Information
Go Biological Process
GDP-L-fucose biosynthetic process (0042350)
Orthologous Events
GDP-fucose biosynthesis (Bos taurus)
GDP-fucose biosynthesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Canis familiaris)
GDP-fucose biosynthesis (Danio rerio)
GDP-fucose biosynthesis (Dictyostelium discoideum)
GDP-fucose biosynthesis (Drosophila melanogaster)
GDP-fucose biosynthesis (Gallus gallus)
GDP-fucose biosynthesis (Mus musculus)
GDP-fucose biosynthesis (Plasmodium falciparum)
GDP-fucose biosynthesis (Rattus norvegicus)
GDP-fucose biosynthesis (Schizosaccharomyces pombe)
GDP-fucose biosynthesis (Sus scrofa)
GDP-fucose biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2015-07-15)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
Jassal, B  (2015-07-15)
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