GDP-fucose biosynthesis

Stable Identifier
R-HSA-6787639
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Fucose-containing glycans play important roles in immunity and signalling. Fucosylated glycans are created by fucosyltransferases, which require the high-energy donor substrate GDP-fucose. Two pathways for the synthesis of GDP-fucose exist in mammalian cells; the GDP-mannose-dependent de novo pathway provides the majority of GDP-fucose whereas a minor contribution comes from the free fucose-dependent salvage pathway (Becker & Lowe 2003).

Literature References
PubMed ID Title Journal Year
12651883 Fucose: biosynthesis and biological function in mammals

Becker, DJ, Lowe, JB

Glycobiology 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created