GMDS dehydrates GDP-Man to GDP-DHDMan

Stable Identifier
R-HSA-6787632
Type
Reaction
Species
Homo sapiens
Compartment
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The de novo synthesis pathway for GDP-L-fucose is a two step pathway starting from GDP-mannose. In the first step, GDP-mannose (GDP-Man) is dehydrated to GDP-4-dehydro-6-deoxy-alpha-D-mannose (GDP-DHDMan) by GDP-mannose 4,6 dehydratase (GMDS) (Sullivan et al. 1998, Ohyama et al. 1998). Fucosylation is one of the most important oligosaccharide modifications in cancer and inflammation. Defects in GMDS are involved in the progression of colorectal cancer (Nakayama et al. 2013).

Literature References
PubMed ID Title Journal Year
9603974 Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells

Lowe, JB, Ohyama, C, Smith, PL, Angata, K, Fukuda, MN, Fukuda, M

J. Biol. Chem. 1998
23922970 Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis

Shinzaki, S, Imai, T, Kamada, Y, Murata, K, Moriwaki, K, Nakayama, K, Miyoshi, E

PLoS ONE 2013
9525924 Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro

Xu, GY, Potvin, B, Sullivan, FX, Rouse, J, Kumar, R, Chang, XJ, Kriz, R, Cumming, DA, Boodhoo, A, Stahl, M

J. Biol. Chem. 1998
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Catalyst Activity

GDP-mannose 4,6-dehydratase activity of GMDS [cytosol]

Orthologous Events
Cross References
Rhea
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