Reactome | DERA cleaves dR5P to GA3P and CH3CHO

DERA cleaves dR5P to GA3P and CH3CHO

Stable Identifier

R-HSA-6787321

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The nucleoside breakdown products ribose-1-phosphate (R1P) and deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect these nucleoside breakdown products to central carbon metabolism in mammals. In the second step, deoxy-ribose5-phosphate (dR5P) is cleaved to glyceraldehyde-3-phosphate (GA3P, an intermediate in glycolysis) and acetaldehyde (CH3CHO) by deoxyribose-phosphate aldolase (DERA) (Salleron et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25229427	DERA is the human deoxyribose phosphate aldolase and is involved in stress response Salleron, L, Magistrelli, G, Mary, C, Fischer, N, Bairoch, A, Lane, L	Biochim. Biophys. Acta	2014