DERA cleaves dR5P to GA3P and CH3CHO

Stable Identifier
R-HSA-6787321
Type
Reaction
Species
Homo sapiens
Compartment
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The nucleoside breakdown products ribose-1-phosphate (R1P) and deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect these nucleoside breakdown products to central carbon metabolism in mammals. In the second step, deoxy-ribose5-phosphate (dR5P) is cleaved to glyceraldehyde-3-phosphate (GA3P, an intermediate in glycolysis) and acetaldehyde (CH3CHO) by deoxyribose-phosphate aldolase (DERA) (Salleron et al. 2014).

Literature References
PubMed ID Title Journal Year
25229427 DERA is the human deoxyribose phosphate aldolase and is involved in stress response

Lane, L, Fischer, N, Mary, C, Bairoch, A, Magistrelli, G, Salleron, L

Biochim. Biophys. Acta 2014
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Catalyst Activity

deoxyribose-phosphate aldolase activity of DERA [cytosol]

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