Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
FLT3LG [extracellular region]
Stable Identifier
R-HSA-6786793
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fms-related tyrosine kinase 3 ligand, FLT3L_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3 binds FYN (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:FYN [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3 binds HCK (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:HCK [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3 binds PTPN11 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3 dimer binds GRB2 (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2 binds GAB2 (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2 binds SOS1 (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer binds FLT3 (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)
FLT3LG dimer:FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3 dimer [plasma membrane] (Homo sapiens)
FLT3LG dimer:FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3 dimer [plasma membrane] (Homo sapiens)
FLT3LG dimer:FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Homo sapiens)
FLT3LG dimer:FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
Active FLT3:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS donwstream of FLT3 (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
STAT5 Activation (Homo sapiens)
Activator phosphorylates STAT5 (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Activators bind STAT5 (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
Activators of STAT5 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Active FLT3:PTPN11 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
Active FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer [extracellular region] (Homo sapiens)
FLT3LG [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49771 FLT3LG
Gene Names
FLT3LG
Chain
signal peptide:1-26, chain:27-235
Reference Genes
BioGPS Gene:2323 FLT3LG
COSMIC (genes):FLT3LG FLT3LG
CTD Gene:2323 FLT3LG
dbSNP Gene:2323 FLT3LG
ENSEMBL:ENSG00000090554 FLT3LG
HGNC:3766 FLT3LG
KEGG Gene (Homo sapiens):2323 FLT3LG
Monarch:2323 FLT3LG
NCBI Gene:2323 FLT3LG
OMIM:600007 FLT3LG
UCSC:P49771 FLT3LG
Reference Transcript
RefSeq:NM_001459.3 FLT3LG
RefSeq:NM_001278638.1 FLT3LG
RefSeq:XM_011526682.2 FLT3LG
RefSeq:NM_001204503.1 FLT3LG
RefSeq:NM_001278637.1 FLT3LG
RefSeq:NM_001204502.1 FLT3LG
Other Identifiers
0002810215
1067_at
1068_g_at
11730099_a_at
11730100_x_at
11744800_x_at
11748850_a_at
16864129
206980_s_at
210607_at
2323
36314_at
3838557
3838558
3838559
3838560
3838561
3838563
3838564
3838565
3838566
3838567
3838568
3838569
3838570
3838571
3838573
3838574
8030339
A_23_P78742
GE88850
GO:0000165
GO:0001934
GO:0002376
GO:0003674
GO:0005102
GO:0005125
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0006464
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009790
GO:0009986
GO:0016020
GO:0016021
GO:0019221
GO:0019899
GO:0030098
GO:0030154
GO:0030885
GO:0030971
GO:0031233
GO:0032819
GO:0032825
GO:0034641
GO:0035162
GO:0042592
GO:0045663
GO:0045787
GO:0045944
GO:0048646
GO:0048856
GO:0048873
GO:0071864
GO:0071866
GO:0090290
GO:1901741
ILMN_2091412
PH_hs_0000051
TC19002605.hg
U03858_at
U04806_s_at
g4503750_3p_a_at
g494978_3p_at
Participant Of
hasComponent
FLT3LG dimer [extracellular region]
Inferred To
FLT3LG [extracellular region] (Bos taurus)
FLT3LG [extracellular region] (Canis familiaris)
FLT3LG [extracellular region] (Sus scrofa)
Ghost homologue of FLT3LG [extracellular region] (Danio rerio)
Ghost homologue of FLT3LG [extracellular region] (Gallus gallus)
Ghost homologue of FLT3LG [extracellular region] (Xenopus tropicalis)
Flt3lg [extracellular region] (Mus musculus)
Flt3lg [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
NP_001191431.1
,
NP_001450.2
,
NP_001265566.1
,
NP_001191432.1
,
XP_011524984.1
,
NP_001265567.1
OpenTargets
ENSG00000090554
GeneCards
P49771
HPA
ENSG00000090554-FLT3LG
Ensembl
ENSP00000471226
,
ENST00000594009
,
ENSG00000090554
,
ENSP00000468977
,
ENSP00000469613
,
ENSP00000204637
,
ENST00000600429
,
ENST00000597551
,
ENSP00000470453
,
ENST00000204637
,
ENST00000595510
PRO
P49771
PDB
3QS9
,
3QS7
,
1ETE
© 2020
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![FLT3LG [extracellular region] icon](/icon/R-ICO-013703.svg){kind=icon}
