Reactome | FLT3LG [extracellular region]

FLT3LG [extracellular region]

Stable Identifier

R-HSA-6786793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Fms-related tyrosine kinase 3 ligand, FLT3L_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - FLT3 signaling in disease (Homo sapiens)
    - FLT3 signaling by CBL mutants (Homo sapiens)
      - CBL mutants don't ubiquitinate FLT3 (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
        
        Active FLT3:CBL mutants [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K-containing complexes [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K-containing complexes [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3: GRB2 [plasma membrane] (Homo sapiens)
        
        Active FLT3 [plasma membrane] (Homo sapiens)
        
        FLT3LG dimer [extracellular region] (Homo sapiens)
        
        FLT3LG [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49771 FLT3LG

Gene Names

FLT3LG

Chain

signal peptide:1-26, chain:27-235

Reference Genes

BioGPS Gene:2323 FLT3LG

COSMIC (genes):FLT3LG FLT3LG

CTD Gene:2323 FLT3LG

dbSNP Gene:2323 FLT3LG

ENSEMBL:ENSG00000090554 FLT3LG

HGNC:3766 FLT3LG

KEGG:hsa:2323 FLT3LG

Monarch:2323 FLT3LG

NCBI Gene:2323 FLT3LG

OMIM:600007 FLT3LG

UCSC:P49771 FLT3LG

Reference Transcript

Other Identifiers

1067_at

1068_g_at

11730099_a_at

11730100_x_at

11744800_x_at

11748850_a_at

16864129

206980_PM_s_at

206980_s_at

210607_PM_at

210607_at

2323

36314_at

3838557

3838558

3838559

3838560

3838561

3838562

3838563

3838564

3838565

3838566

3838567

3838568

3838569

3838570

3838571

3838573

3838574

8030339

A_14_P106481

A_23_P78742

GE81025

GE88850

GO:0005102

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005886

GO:0007165

GO:0008284

GO:0009986

GO:0016020

GO:0030971

GO:0035162

GO:0048018

GO:0048856

GO:0098772

HMNXSV003035875

HMNXSV003050235

ILMN_2091412

PH_hs_0000051

TC19002605.hg

U03858_at

U04806_s_at

g4503750_3p_a_at

g494978_3p_at

Participates

as a component of

FLT3LG dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

FLT3LG [cytosol]

Inferred To

FLT3LG [extracellular region] (Bos taurus)

FLT3LG [extracellular region] (Canis familiaris)

FLT3LG [extracellular region] (Sus scrofa)

Ghost homologue of FLT3LG [extracellular region] (Caenorhabditis elegans)

Ghost homologue of FLT3LG [extracellular region] (Drosophila melanogaster)

Ghost homologue of FLT3LG [extracellular region] (Gallus gallus)

Ghost homologue of FLT3LG [extracellular region] (Rattus norvegicus)

Ghost homologue of FLT3LG [extracellular region] (Xenopus tropicalis)

Flt3lg [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001265566.1, NP_001265567.1, NP_001191431.1, NP_001191432.1, XP_011524984.1, NP_001450.2

OpenTargets

ENSG00000090554

ENSEMBL

ENSP00000470453, ENSP00000204637, ENSP00000469613, ENSP00000468977, ENST00000204637, ENST00000597551, ENST00000595510, ENSG00000090554, ENSP00000471226, ENST00000600429, ENST00000594009

HPA

ENSG00000090554-FLT3LG

GeneCards

FLT3LG

PRO

P49771

Pharos - Targets

P49771

GlyGen

P49771

PDB

7NBI, 7ZV9, 7QDP, 3QS7, 3QS9, 1ETE

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