TRMT10A methylates guanosine-9 in tRNA

Stable Identifier
R-HSA-6786621
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRMT10A methylates guanosine-9 in tRNA
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As inferred from the homologue in Saccharomyces cerevisiae, TRMT10A methylates the 1 position of guanosine at nucleotide 9 of tRNAs. TRMT10A is located in the nucleus (Igoillo-Esteve et al. 2013). A nonsense mutation in TRMT10A causes diabetes and microcephaly (Igoillo-Esteve et al. 2013).
Literature References
PubMed ID Title Journal Year
23042678 A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis

Vilardo, E, Nachbagauer, C, Buzet, A, Taschner, A, Holzmann, J, Rossmanith, W

Nucleic Acids Res. 2012
24204302 tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

Igoillo-Esteve, M, Genin, A, Lambert, N, Désir, J, Pirson, I, Abdulkarim, B, Simonis, N, Drielsma, A, Marselli, L, Marchetti, P, Vanderhaeghen, P, Eizirik, DL, Wuyts, W, Julier, C, Chakera, AJ, Ellard, S, Hattersley, AT, Abramowicz, M, Cnop, M

PLoS Genet. 2013
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanosine(9)-N1)-methyltransferase activity of TRMT10A [nucleoplasm]

Physical Entity
TRMT10A [nucleoplasm] (Homo sapiens)
Activity
tRNA (guanosine(9)-N1)-methyltransferase activity (GO:0052905)
Inferred From
TRM10 methylates guanosine-9 in tRNA (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-07-09)
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