TRMT10A methylates guanosine-9 in tRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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As inferred from the homologue in Saccharomyces cerevisiae, TRMT10A methylates the 1 position of guanosine at nucleotide 9 of tRNAs. TRMT10A is located in the nucleus (Igoillo-Esteve et al. 2013). A nonsense mutation in TRMT10A causes diabetes and microcephaly (Igoillo-Esteve et al. 2013).

Literature References
PubMed ID Title Journal Year
23042678 A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis

Taschner, A, Vilardo, E, Rossmanith, W, Holzmann, J, Buzet, A, Nachbagauer, C

Nucleic Acids Res. 2012
24204302 tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

Julier, C, Drielsma, A, Hattersley, AT, Vanderhaeghen, P, Pirson, I, Abdulkarim, B, Abramowicz, M, Eizirik, DL, Lambert, N, Cnop, M, Ellard, S, Simonis, N, Genin, A, Marchetti, P, Wuyts, W, Marselli, L, D├ęsir, J, Igoillo-Esteve, M, Chakera, AJ

PLoS Genet. 2013
Event Information
Go Biological Process
Catalyst Activity

tRNA (guanine-N1-)-methyltransferase activity of TRMT10A [nucleoplasm]

Inferred From
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