TRMT10A methylates guanosine-9 in tRNA

Stable Identifier
R-HSA-6786621
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRMT10A methylates guanosine-9 in tRNA
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As inferred from the homologue in Saccharomyces cerevisiae, TRMT10A methylates the 1 position of guanosine at nucleotide 9 of tRNAs. TRMT10A is located in the nucleus (Igoillo-Esteve et al. 2013). A nonsense mutation in TRMT10A causes diabetes and microcephaly (Igoillo-Esteve et al. 2013).
Literature References
PubMed ID Title Journal Year
23042678 A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis

Taschner, A, Vilardo, E, Rossmanith, W, Holzmann, J, Buzet, A, Nachbagauer, C

Nucleic Acids Res. 2012
24204302 tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

Julier, C, Drielsma, A, Hattersley, AT, Vanderhaeghen, P, Pirson, I, Abdulkarim, B, Abramowicz, M, Eizirik, DL, Lambert, N, Cnop, M, Ellard, S, Simonis, N, Genin, A, Marchetti, P, Wuyts, W, Marselli, L, Désir, J, Igoillo-Esteve, M, Chakera, AJ

PLoS Genet. 2013
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanosine(9)-N1)-methyltransferase activity of TRMT10A [nucleoplasm]

Physical Entity
TRMT10A [nucleoplasm] (Homo sapiens)
Activity
tRNA (guanosine(9)-N1)-methyltransferase activity (GO:0052905)
Inferred From
TRM10 methylates guanosine-9 in tRNA (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-07-09)
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