PUS7 transforms uridine to pseudouridine in tRNAs

Stable Identifier
R-HSA-6786583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PUS7 transforms uridine to pseudouridine in tRNAs
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As inferred from the homologue in Saccharmyces cerivisiae, PUS7 converts uridine to pseudouridine at nucleotide 13 of cytoplasmic tRNA and at nucleotide 35 of unspliced tRNA(Tyr). PUS7 also synthesizes pseudouridine in U2 snRNA and in pre-tRNA(Tyr). Pus7p is a nuclear protein according to global analysis of protein locations in yeast.
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

pseudouridine synthase activity of PUS7 [nucleoplasm]

Physical Entity
PUS7 [nucleoplasm] (Homo sapiens)
Activity
pseudouridine synthase activity (GO:0009982)
Inferred From
PUS7 transforms uridine to pseudouridine at nucleotide 13 of tRNA (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-07-09)
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