KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine

Stable Identifier
R-HSA-6786567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
KIAA1456 (TRM9L, hTRM9L) transfers a methyl group from S-adenosylmethionine (AdoMet) to 5-carboxymethyluridine in tRNA, yielding 5-methoxycarbonylmethyluridine (5-(2-methoxy-2-oxoethyl)uridine) (Begley et al. 2013). The subcellular location of the reaction is unknown.
Literature References
PubMed ID Title Journal Year
23381944 A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

Begley, T, Dedon, PC, Endres, L, Sosa, MS, Chan, CT, Estrada, Y, Patil, A, Avivar-Valderas, A, Aguirre-Ghiso, JA, Su, D, Begley, U

EMBO Mol Med 2013
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA methyltransferase activity of KIAA1456 [cytoplasm]

Physical Entity
KIAA1456 [cytoplasm] (Homo sapiens)
Activity
tRNA methyltransferase activity (GO:0008175)
Authored
May, B  (2015-06-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-07-09)
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