KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine

Stable Identifier
R-HSA-6786567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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KIAA1456 (TRM9L, hTRM9L) transfers a methyl group from S-adenosylmethionine (AdoMet) to 5-carboxymethyluridine in tRNA, yielding 5-methoxycarbonylmethyluridine (5-(2-methoxy-2-oxoethyl)uridine) (Begley et al. 2013). The subcellular location of the reaction is unknown.

Literature References
PubMed ID Title Journal Year
23381944 A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

Begley, U, Sosa, MS, Avivar-Valderas, A, Patil, A, Endres, L, Estrada, Y, Chan, CT, Su, D, Dedon, PC, Aguirre-Ghiso, JA, Begley, T

EMBO Mol Med 2013
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Catalyst Activity
Catalyst Activity
Title
tRNA methyltransferase activity of KIAA1456 [cytoplasm]
Physical Entity
Activity
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