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Core 2S (MUC16) [Golgi lumen]
Stable Identifier
R-HSA-6786361
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Core 2 (MUC16), MUC16, MUC16_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)
Core 2S mucins [Golgi lumen] (Homo sapiens)
Core 2S (MUC16) [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WXI7 MUC16
Gene Names
MUC16, CA125
Chain
chain:1-14507
Reference Genes
BioGPS Gene:94025 MUC16
COSMIC (genes):MUC16 MUC16
CTD Gene:94025 MUC16
dbSNP Gene:94025 MUC16
ENSEMBL:ENSG00000181143 MUC16
ENSEMBL_homo_sapiens_GENE:ENSG00000181143.17 MUC16
HGNC:15582 MUC16
KEGG Gene (Homo sapiens):94025 MUC16
Monarch:94025 MUC16
NCBI Gene:94025 MUC16
OMIM:606154 MUC16
UCSC:Q8WXI7 MUC16
Reference Transcript
RefSeq:NM_024690.2 MUC16
Other Identifiers
11715343_at
16868265
220196_PM_at
220196_at
3849299
3849300
3849301
3849302
3849304
3849305
3849306
3849307
3849309
3849311
3849312
3849313
3849315
3849316
3849317
3849318
3849319
3849320
3849321
3849323
3849324
3849326
3849327
3849328
3849329
3849330
3849331
3849332
3849333
3849335
3849336
3849338
3849340
3849341
3849342
3849343
3849345
3849347
3849348
3849349
3849350
3849351
3849352
3849353
3849354
3849355
3849357
3849359
3849360
3849361
3849362
3849363
3849365
3849366
3849367
3849368
3849370
3849372
3849373
3849374
3849375
3849377
3849379
3849380
3849381
3849382
3849383
3849384
3849385
3849387
3849388
3849389
3849390
3849391
3849393
3849394
3849396
3849397
3849398
3849399
3849400
3849402
3849403
3849404
3849406
3849408
3849410
3849412
3849414
3849416
3849418
3849420
3849421
3849422
3849423
3849424
3849425
3849426
3849427
49094_at
8033674
94025
A_23_P5211
A_33_P3313110
GE531235
GE82902
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005796
GO:0005886
GO:0007155
GO:0009897
GO:0016020
GO:0031982
GO:0043226
GO:0070062
HMNXSV003002490
ILMN_1736316
ILMN_2125346
PH_hs_0025254
TC19001139.hg
g13375965_3p_at
Participates
as a member of
Core 2S mucins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
Core 8 (MUC16) [Golgi lumen]
Core 5 (MUC16) [Golgi lumen]
Core 4 (MUC16) [Golgi lumen]
Core 3 (MUC16) [Golgi lumen]
Core 7 (MUC16) [Golgi lumen]
extended Core 6 (MUC16) [Golgi lumen]
GalNAc-MUC16 [plasma membrane]
Core 2 (MUC16) [Golgi lumen]
Core 2a (MUC16) [Golgi lumen]
GalNAc-MUC16 [Golgi lumen]
Sialyl Tn antigen (MUC16) [Golgi lumen]
T-antigen (MUC16) [Golgi lumen]
Sialyl-2,3 T-antigen (MUC16) [Golgi lumen]
Sialyl T-antigen (MUC16) [Golgi lumen]
Disialyl T-antigen (MUC16) [Golgi lumen]
MUC16 [Golgi lumen]
Core 6 (MUC16) [Golgi lumen]
Inferred To
Muc16 [Golgi lumen]
(Mus musculus)
LOC116412004 [Golgi lumen]
(Xenopus tropicalis)
Core 2S (MUC16) [Golgi lumen]
(Bos taurus)
Core 2S (MUC16) [Golgi lumen]
(Canis familiaris)
Core 2S (MUC16) [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-(N-acetylamino)galactosyl-L-serine (6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)-(beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group) at unknown position
Modification
6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)-(beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group
PsiMod Name
O-(N-acetylamino)galactosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.
Cross References
RefSeq
NP_078966.2
OpenTargets
ENSG00000181143
GeneCards
Q8WXI7
HPA
ENSG00000181143-MUC16
Ensembl
ENSP00000381008
,
ENSG00000181143
,
ENST00000397910
PRO
Q8WXI7
Pharos - Targets
Q8WXI7
PDB
8VRS
,
8GKL
,
7SA9
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