CMBL hydrolyses OM to OLMS

Stable Identifier
R-HSA-6786190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carboxymethylenebutenolidase homolog (CMBL) is a cytosolic hydrolase enzyme present in liver and intestine. It is able to hydrolyse medoxomil-type pro-drugs to their pharmacologically active metabolites. Olmesartan medoxomil (OM) is an angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. It is hydrolysed by CMBL to its active metabolite olmesartan (OLMS) (Ishizuka et al 2010). True physiological substrates of CMBL remain unknown.

Literature References
PubMed ID Title Journal Year
20177059 Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine

Ishizuka, T, Fujimori, I, Kato, M, Noji-Sakikawa, C, Saito, M, Yoshigae, Y, Kubota, K, Kurihara, A, Izumi, T, Ikeda, T, Okazaki, O

J. Biol. Chem. 2010
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Catalyst Activity

hydrolase activity of CMBL [cytosol]

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