Reactome | CMBL hydrolyses OM to OLMS

CMBL hydrolyses OM to OLMS

Stable Identifier

R-HSA-6786190

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Carboxymethylenebutenolidase homolog (CMBL) is a cytosolic hydrolase enzyme present in liver and intestine. It is able to hydrolyse medoxomil-type pro-drugs to their pharmacologically active metabolites. Olmesartan medoxomil (OM) is an angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. It is hydrolysed by CMBL to its active metabolite olmesartan (OLMS) (Ishizuka et al 2010). True physiological substrates of CMBL remain unknown.

Literature References

PubMed ID	Title	Journal	Year
20177059	Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine Ikeda, T, Saito, M, Kurihara, A, Kubota, K, Yoshigae, Y, Fujimori, I, Ishizuka, T, Okazaki, O, Noji-Sakikawa, C, Izumi, T, Kato, M	J. Biol. Chem.	2010