Reactome | IL4:IL4R:JAK2 binds IL2RG:JAK3

IL4:IL4R:JAK2 binds IL2RG:JAK3

Stable Identifier

R-HSA-6786092

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin 2 receptor gamma subunit (IL2RG), with constitutively-associated Janus kinase 3 (JAK3), binds the IL4:IL4R:JAK2 complex, interacting with IL4 and IL4R to form the ligand-bound type I IL4 receptor complex, IL4R1 (LaPorte et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18243101	Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system Laporte, SL, Juo, ZS, Vaclavikova, J, Colf, LA, Qi, X, Heller, NM, Keegan, AD, Garcia, KC	Cell	2008