IL4:IL4R:JAK2 binds IL2RG:JAK3

Stable Identifier
R-HSA-6786092
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL4:IL4R:JAK2 binds IL2RG:JAK3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin 2 receptor gamma subunit (IL2RG), with constitutively-associated Janus kinase 3 (JAK3), binds the IL4:IL4R:JAK2 complex, interacting with IL4 and IL4R to form the ligand-bound type I IL4 receptor complex, IL4R1 (LaPorte et al. 2008).

Literature References
PubMed ID Title Journal Year
18243101 Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Laporte, SL, Juo, ZS, Vaclavikova, J, Colf, LA, Qi, X, Heller, NM, Keegan, AD, Garcia, KC

Cell 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Canis familiaris)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Rattus norvegicus)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
Cite Us!