Reactome | IL4:IL4R:JAK2 binds IL13RA1:TYK2

IL4:IL4R:JAK2 binds IL13RA1:TYK2

Stable Identifier

R-HSA-6786070

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Interleukin-13 receptor subunit alpha-1 (IL13RA1), with associated Non-receptor tyrosine-protein kinase 2 (TYK2), binds the IL4:IL4R:JAK2 complex to form the ligand-bound Type II IL4 receptor complex (IL4R2). IL4R2 is predominantly expressed on the surface of non-hematopoietic cells. It is also a receptor for Interleukin-13 (IL13) (Obiri et al. 1995, Aman et al. 1996, Hilton et al. 1996). Crystal structures of the IL4:IL4R:IL13RA1 and IL13:IL4R:IL13RA1 complexes have been determined (LaPorte et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18243101	Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system Laporte, SL, Juo, ZS, Vaclavikova, J, Colf, LA, Qi, X, Heller, NM, Keegan, AD, Garcia, KC	Cell	2008