IL4:IL4R:JAK2 binds IL13RA1:TYK2

Stable Identifier
R-HSA-6786070
Type
Reaction [binding]
Species
Homo sapiens
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Interleukin-13 receptor subunit alpha-1 (IL13RA1), with associated Non-receptor tyrosine-protein kinase 2 (TYK2), binds the IL4:IL4R:JAK2 complex to form the ligand-bound Type II IL4 receptor complex (IL4R2). IL4R2 is predominantly expressed on the surface of non-hematopoietic cells. It is also a receptor for Interleukin-13 (IL13) (Obiri et al. 1995, Aman et al. 1996, Hilton et al. 1996). Crystal structures of the IL4:IL4R:IL13RA1 and IL13:IL4R:IL13RA1 complexes have been determined (LaPorte et al. 2008).

Literature References
PubMed ID Title Journal Year
18243101 Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Laporte, SL, Juo, ZS, Vaclavikova, J, Colf, LA, Qi, X, Heller, NM, Keegan, AD, Garcia, KC

Cell 2008
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