CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1

Stable Identifier
Reaction [transition]
Homo sapiens
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Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 3 of non-reducing glucuronyl (GlcA) residues of N-glycosylated proteins terminating with the saccharide sequence glucuronyl-lactosaminyl (GlcA-LacN), forming the HNK1 carbohydrate (sulfo-3GlcA-beta1,3Gal-beta1,4-GlcNAc-R). The HNK1 carbohydrate is expressed on various adhesion molecules (neural cells, natural killer cells) in the nervous system and may play a role in cell-cell and cell-substratum interactions (Ong et al. 1998, 1999).

Literature References
PubMed ID Title Journal Year
10464296 Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis

Ong, E, Yeh, JC, Ding, Y, Hindsgaul, O, Pedersen, LC, Negishi, M, Fukuda, M

J. Biol. Chem. 1999
9478973 Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids

Ong, E, Yeh, JC, Ding, Y, Hindsgaul, O, Fukuda, M

J. Biol. Chem. 1998
Catalyst Activity

HNK-1 sulfotransferase activity of CHST10 [Golgi membrane]

Orthologous Events
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