CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1

Stable Identifier
R-HSA-6786048
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 3 of non-reducing glucuronyl (GlcA) residues of N-glycosylated proteins terminating with the saccharide sequence glucuronyl-lactosaminyl (GlcA-LacN), forming the HNK1 carbohydrate (sulfo-3GlcA-beta1,3Gal-beta1,4-GlcNAc-R). The HNK1 carbohydrate is expressed on various adhesion molecules (neural cells, natural killer cells) in the nervous system and may play a role in cell-cell and cell-substratum interactions (Ong et al. 1998, 1999).

Literature References
PubMed ID Title Journal Year
10464296 Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis

Ong, E, Yeh, JC, Ding, Y, Hindsgaul, O, Pedersen, LC, Negishi, M, Fukuda, M

J. Biol. Chem. 1999
9478973 Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids

Ong, E, Yeh, JC, Ding, Y, Hindsgaul, O, Fukuda, M

J. Biol. Chem. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
HNK-1 sulfotransferase activity of CHST10 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created