Reactome | CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1

CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1

Stable Identifier

R-HSA-6786048

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)

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CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1

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Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 3 of non-reducing glucuronyl (GlcA) residues of N-glycosylated proteins terminating with the saccharide sequence glucuronyl-lactosaminyl (GlcA-LacN), forming the HNK1 carbohydrate (sulfo-3GlcA-beta1,3Gal-beta1,4-GlcNAc-R). The HNK1 carbohydrate is expressed on various adhesion molecules (neural cells, natural killer cells) in the nervous system and may play a role in cell-cell and cell-substratum interactions (Ong et al. 1998, 1999).

Literature References

PubMed ID	Title	Journal	Year
9478973	Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids Hindsgaul, O, Ong, E, Fukuda, M, Ding, Y, Yeh, JC	J. Biol. Chem.	1998
10464296	Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis Negishi, M, Hindsgaul, O, Pedersen, LC, Ong, E, Fukuda, M, Ding, Y, Yeh, JC	J. Biol. Chem.	1999