Reactome | CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin

CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin

Stable Identifier

R-HSA-6786034

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)

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CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin

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Carbohydrate sulfotransferase 8 (CHST8) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues of N-glycosylated proteins terminating with the saccharide sequence SO(4)-4-GalNAc-beta1,4-GlcNAc-beta1,2-Man-alpha. This sequence is present on the pituitary hormones lutropin (LH), thyrotropin and pro-opiomelanocortin. The sulfated oligosaccharides on LH are essential for its biologic function (Xia et al. 2000, Hiraoka et al. 2001). LH is required for the production of the sex hormones estradiol, progesterone, and testosterone. The unique saccharide signature is used for clearing LH from blood. Ablation of Chst8 in mice exhibited increased levels of circulating LH resulting in precocious sexual maturation (Mi et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11445554	Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1-->4GlcNAc beta 1-->R in both N- and O-glycans Hiraoka, N, Misra, A, Belot, F, Hindsgaul, O, Fukuda, M	Glycobiology	2001
10988300	Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase Xia, G, Evers, MR, Kang, HG, Schachner, M, Baenziger, JU	J. Biol. Chem.	2000
18431515	Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice Mi, Y, Fiete, D, Baenziger, JU	J. Clin. Invest.	2008