CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin

Stable Identifier
R-HSA-6786034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carbohydrate sulfotransferase 8 (CHST8) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues of N-glycosylated proteins terminating with the saccharide sequence SO(4)-4-GalNAc-beta1,4-GlcNAc-beta1,2-Man-alpha. This sequence is present on the pituitary hormones lutropin (LH), thyrotropin and pro-opiomelanocortin. The sulfated oligosaccharides on LH are essential for its biologic function (Xia et al. 2000, Hiraoka et al. 2001). LH is required for the production of the sex hormones estradiol, progesterone, and testosterone. The unique saccharide signature is used for clearing LH from blood. Ablation of Chst8 in mice exhibited increased levels of circulating LH resulting in precocious sexual maturation (Mi et al. 2008).

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Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acetylgalactosamine 4-O-sulfotransferase activity of CHST8 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created