Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyper-responsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the cytoplasmic protein Suppressor of cytokine signaling 1 (SOCS1) (Hebenstreit et al. 2003).