Expression of SOCS1

Stable Identifier
R-HSA-6785860
Type
Reaction [omitted]
Species
Homo sapiens
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Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyper-responsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the cytoplasmic protein Suppressor of cytokine signaling 1 (SOCS1) (Hebenstreit et al. 2003).

Literature References
PubMed ID Title Journal Year
16540365 Signaling mechanisms, interaction partners, and target genes of STAT6

Hebenstreit, D, Wirnsberger, G, Horejs-Hoeck, J, Duschl, A

Cytokine Growth Factor Rev. 2006
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