SOCS5,(SOCS1) bind IL4RA

Stable Identifier
R-HSA-6785821
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SOCS5 can bind the type I IL4R, reducing its association with JAK1, which results in the inhibition of IL4-mediated STAT6 activation (Seki et al. 2002). Similarly SOCS1 serves as a regulator of IL-4 signaling, diminishing the magnitude and duration of STAT6 activation (Dickensheets et al. 2007).

Literature References
PubMed ID Title Journal Year
16451196 SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation

Davey, GM, Heath, WR, Starr, R

Tissue Antigens 2006
12242343 Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

Seki, Y, Hayashi, K, Matsumoto, A, Seki, N, Tsukada, J, Ransom, J, Naka, T, Kishimoto, T, Yoshimura, A, Kubo, M

Proc. Natl. Acad. Sci. U.S.A. 2002
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