Reactome | SOCS5,(SOCS1) bind IL4RA

SOCS5,(SOCS1) bind IL4RA

Stable Identifier

R-HSA-6785821

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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SOCS5 can bind the type I IL4R, reducing its association with JAK1, which results in the inhibition of IL4-mediated STAT6 activation (Seki et al. 2002). Similarly SOCS1 serves as a regulator of IL-4 signaling, diminishing the magnitude and duration of STAT6 activation (Dickensheets et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
12242343	Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation Seki, Y, Hayashi, K, Matsumoto, A, Seki, N, Tsukada, J, Ransom, J, Naka, T, Kishimoto, T, Yoshimura, A, Kubo, M	Proc. Natl. Acad. Sci. U.S.A.	2002
16451196	SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation Davey, GM, Heath, WR, Starr, R	Tissue Antigens	2006