NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)

Stable Identifier
R-HSA-6785438
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)
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NSUN2 transfers methyl groups from S-adenosylmethionine to the 5 positions of cytidine-40, cytidine-48, cytidine-49, and cytidine-50 of tRNA(Gly)(GCC) (Auxilien et al. 2012, Khoddami and Cairns 2013).
Literature References
PubMed ID Title Journal Year
22995836 The human tRNA m (5) C methyltransferase Misu is multisite-specific

Auxilien, S, Guérineau, V, Szweykowska-Kulińska, Z, Golinelli-Pimpaneau, B

RNA Biol 2012
23604283 Identification of direct targets and modified bases of RNA cytosine methyltransferases

Khoddami, V, Cairns, BR

Nat. Biotechnol. 2013
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (cytidine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]

Physical Entity
NSUN2 [nucleoplasm] (Homo sapiens)
Activity
tRNA (cytidine-5-)-methyltransferase activity (GO:0016428)
Authored
May, B  (2015-06-27)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-27)
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