Negative regulation by 'PTPRK [plasma membrane]'

Stable Identifier
R-HSA-6785334
Type
NegativeRegulation
Locations in the PathwayBrowser
Summation

Receptor-type tyrosine-protein phosphatase kappa (PTPRK/RPTPk/DEP1) dephosphorylates EGFR, thereby inhibiting receptor ubiquitylation (Ub) by c-CBL, which decelerates the rate of receptor internalization and diminishes MAPK signals generated at the membrane and in endosomes. PTPRK disrupts physical association of ubiquitin ligase complex with EGFR and impairs its internalization (Tarcic et al. 2009, Xu et al. 2005).

Regulation participants
Regulation type
NegativeRegulation