p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B

Stable Identifier
R-HSA-6785165
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 5A or 5B (STAT5A and/or STAT5B, typically referred to as STAT5) are phosphorylated after Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011). Interleukin-7 (IL7)-activated Signal transducer and activator of transcription 5A or 5B (typically referred to as STAT5) translocates to the nucleus (Landires et al. 2011) and is recruited rapidly to the promoters of IL7-regulated genes (Ye et al. 2001, Stanton & Brodeur 2005). This is a black box event because dissociation is inferred from the subsequent translocation of STAT5 to the nucleus.

Literature References
PubMed ID Title Journal Year
7489741 Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Foxwell, BM, Beadling, C, Guschin, D, Kerr, I, Cantrell, D

Eur J Immunol 1995
8709637 Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain

van der Plas, DC, Smiers, F, Pouwels, K, Hoefsloot, LH, Löwenberg, B, Touw, IP

Leukemia 1996
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Orthologous Events
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