Reactome | TNFRSF1B(27-?) [plasma membrane]

TNFRSF1B(27-?) [plasma membrane]

Stable Identifier

R-HSA-6785037

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 1B, TNR1B_HUMAN, Tumor necrosis factor-binding protein 2, p75 TNFR

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20333 TNFRSF1B

Gene Names

TNFRSF1B, TNFBR, TNFR2

Chain

signal peptide:1-22, chain:23-461, chain:27-

Reference Genes

BioGPS Gene:7133 TNFRSF1B

COSMIC (genes):TNFRSF1B TNFRSF1B

CTD Gene:7133 TNFRSF1B

dbSNP Gene:7133 TNFRSF1B

ENSEMBL:ENSG00000028137 TNFRSF1B

ENSEMBL_homo_sapiens_GENE:ENSG00000028137.19 TNFRSF1B

HGNC:11917 TNFRSF1B

KEGG Gene (Homo sapiens):7133 TNFRSF1B

Monarch:7133 TNFRSF1B

NCBI Gene:7133 TNFRSF1B

OMIM:191191 TNFRSF1B

UCSC:P20333 TNFRSF1B

Reference Transcript

RefSeq:NM_001066.2 TNFRSF1B

Other Identifiers

11718807_at

11753025_a_at

11755013_x_at

1583_at

16659238

203508_PM_at

203508_at

2320728

2320729

2320735

2320736

2320737

2320738

2320740

2320742

2320744

2320745

2320749

2320751

2320752

2320753

2320754

2320755

2320756

2320757

33813_at

7133

7896721

7897877

A_24_P54174

A_33_P3322274

GE57933

GO:0002376

GO:0002718

GO:0002724

GO:0002947

GO:0003012

GO:0003176

GO:0003177

GO:0003332

GO:0005031

GO:0005515

GO:0005576

GO:0005886

GO:0006915

GO:0006954

GO:0006955

GO:0007166

GO:0008630

GO:0010614

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0030163

GO:0030198

GO:0030424

GO:0031410

GO:0031625

GO:0031641

GO:0031643

GO:0032496

GO:0033209

GO:0035579

GO:0042129

GO:0043025

GO:0043120

GO:0043196

GO:0043226

GO:0045121

GO:0048471

GO:0048714

GO:0048856

GO:0050728

GO:0050779

GO:0051044

GO:0060089

GO:0071222

GO:0071356

GO:0071363

GO:0097191

GO:0150077

GO:0150079

GO:0150098

GO:1902339

HMNXSV003033485

HMNXSV003037451

ILMN_1764788

M32315_at

PH_hs_0013490

PH_hs_0032350

TC01000155.hg

g4507576_3p_at

g4507576_3p_x_at

Participates

as a member of

IL10-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

TNFRSF1B [specific granule membrane]

TNFRSF1B [plasma membrane]

Cross References

RefSeq

NP_001057.1

Guide to Pharmacology - Targets

1871

OpenTargets

ENSG00000028137

GeneCards

P20333

HPA

ENSG00000028137-TNFRSF1B

Ensembl

ENSG00000028137, ENST00000376259, ENSP00000365435

PRO

P20333

Pharos - Targets

P20333

Orphanet

23578

PDB

3ALQ, 8HLB, 1CA9

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.678	4
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.644	5
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.609	2
UniProt:Q9NQH7 XPP3			0.564	2
UniProt:P11182 DBT	11	DBT [cytosol] (R-HSA-9714663) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051)	0.564	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.547	2